Mardani, Mahnaz. and Bahmani, Mahmoud. and Moradmand Jalali, S. and Salehi, A. and Davoodi, M. and Ghobadi, S. and Rezapour, P. and Rafieian-Kopaei, Mahmoud. (2016) Comparison of the descurainia sophia and levostatin effect on the ldl cholesterol reduction, a clinical trial study. Journal of Chemical and Pharmaceutical Sciences, 9 (3). pp. 1329-1333.
Full text not available from this repository.Abstract
Hypercholesterolemia is the major risk factor for cardiovascular diseases. Considering the high prevalence of CVD in Khorramabad city, and the inhibitory effects of flavonoides on the LDL cholesterol oxidation, and the flavonoides present in Descurainia Sophia, the aim of this study was to compare the effects of Descurainia sophia and levostatin on LDL cholesterol reduction for the first time. This research was carried out as a double blind study on 80 cardiovascular patients with high LDL cholesterol. Sampling was carried out by consecutive non probability. All patients signed the informed consent form and were randomly divided into two groups: A= intervention group that take 20mg of lovastatin with dinner + 8 grams of D.sophia per day before lunch, B= control group that take 20mg of lovastatin with dinner+ placebo per day before lunch. LDL cholesterol of all patients was measured before and after 5 months of the intervention. The mean and the standard deviation of LDL cholesterol in the intervention group were 209.40±52.649 and 106.85±23.368 before and after intervention, respectively. It was 198.50±38.443 and 108.233±841 in the control group. This difference was not proven statistically meaningful. Results showed that consumption of 8 grams of D.sophia per day+ lovastatin can reduce the LDL level of the patients' serum, although this reduction was not meaningful in comparison to the lovastatin. We propose that more thorough studies must be carried out to achieve further results about the effect of Descurainia sophia on LDL cholesterol.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | Cardiovascular disease, Cholesterol, Descurainia sophia, Flavonoids |
| Subjects: | QU Biochemistry QV pharmacology > QV 752 Pharmacognosy |
| Divisions: | Reserach Vice-Chancellar Department > Medical Plants Research Center |
| Depositing User: | Users 1 not found. |
| Date Deposited: | 09 Jul 2017 04:34 |
| Last Modified: | 11 Jun 2018 07:37 |
| URI: | http://eprints.skums.ac.ir/id/eprint/1056 |
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