Therapeutic mechanisms of fibroblast cells in the skin conditions; trends in clinical applications- A Review

Rostamzadeh, Ayoob. and Amiri Andi, Safar Ali. and Moayeri, Ardeshir. (2016) Therapeutic mechanisms of fibroblast cells in the skin conditions; trends in clinical applications- A Review. Journal of Chemical and Pharmaceutical Sciences, 9 (4). pp. 2836-2841.

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Abstract

Autologous cells in cell therapy is useful in accelerating the Curing course of lesions through reducing time required for early synthesis of new derm by the host cells to invade the lesion tissue. Collagen and hyaluronic acid matrices are also effective in accelerating the lesion curing process. They increase migration of host cells and blood vessels into the tissue and allow rapid replacement by host tissue. The cell-scaffold complex is grafted onto the defect area and covered with a polyurethane foam dressing. Practical challenges including scale up, formulation, storage, transport and delivery mechanisms are the main challenges to development and clinical translation of preclinical observations. However, recent FDA consent of fibroblast treatment applications for nasolabial folds and the expanding pipeline of other fibroblast therapies in clinical development show that cellular therapy is an expanding field.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Curingو Derm condition, Derm rejuvenation, Fibroblast, Therapeutic, Transplantation, Ulcer
Subjects: WR Dermatology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Depositing User: Users 1 not found.
Date Deposited: 15 Jul 2017 06:00
Last Modified: 23 Jul 2018 05:16
URI: http://eprints.skums.ac.ir/id/eprint/995

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