Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019

Cousin, Ewerton and Duncan, Bruce B and Stein, Caroline and Ong, Kanyin Liane and Vos, Theo and Abbafati, Cristiana and Abbasi-Kangevari, Mohsen and Abdelmasseh, Michael and Abdoli, Amir and Abd-Rabu, Rami and Abolhassani, Hassan and Abu-Gharbieh, Eman and Accrombessi, Manfred Mario Kokou and Adnani, Qorinah Estiningtyas Sakilah and Afzal, Muhammad Sohail and Agarwal, Gina and Agrawaal, Krishna K and Agudelo-Botero, Marcela and Ahinkorah, Bright Opoku and Ahmad, Sajjad and Ahmad, Tauseef and Ahmadi, Keivan and Ahmadi, Sepideh and Ahmadi, Ali and Ahmed, Ali and Ahmed Salih, Yusra and Akande-Sholabi, Wuraola and Akram, Tayyaba and Al Hamad, Hanadi and Al-Aly, Ziyad and Alcalde-Rabanal, Jacqueline Elizabeth and Alipour, Vahid and Aljunid, Syed Mohamed and Al-Raddadi, Rajaa M and Alvis-Guzman, Nelson and Amini, Saeed and Ancuceanu, Robert and Andrei, Tudorel and Andrei, Catalina Liliana and Anjana, Ranjit Mohan and Ansar, Adnan and Antonazzo, Ippazio Cosimo and Antony, Benny and Anyasodor, Anayochukwu Edward and Arabloo, Jalal and Arizmendi, Damian and Armocida, Benedetta and Artamonov, Anton A and Arulappan, Judie and Aryan, Zahra and Asgari, Samaneh and Ashraf, Tahira and Astell-Burt, Thomas and Atorkey, Prince and Atout, Maha Moh'd Wahbi and Ayanore, Martin Amogre and Badiye, Ashish D and Baig, Atif Amin and Bairwa, Mohan and Baker, Jennifer L and Baltatu, Ovidiu Constantin and Banik, Palash Chandra and Barnett, Anthony and Barone, Mark Thomaz Ugliara and Barone-Adesi, Francesco and Barrow, Amadou and Bedi, Neeraj and Belete, Rebuma and Belgaumi, Uzma Iqbal and Bell, Arielle Wilder and Bennett, Derrick A and Bensenor, Isabela M and Beran, David and Bhagavathula, Akshaya Srikanth and Bhaskar, Sonu and Bhattacharyya, Krittika and Bhojaraja, Vijayalakshmi S and Bijani, Ali and Bikbov, Boris and Birara, Setognal and Bodolica, Virginia and Bonny, Aime and Brenner, Hermann and Briko, Nikolay Ivanovich and Butt, Zahid A and Caetano dos Santos, Florentino Luciano and Cámera, Luis Alberto and Campos-Nonato, Ismael R and Cao, Yin and Cao, Chao and Cerin, Ester and Chakraborty, Promit Ananyo and Chandan, Joht Singh and Chattu, Vijay Kumar and Chen, Simiao and Choi, Jee-Young Jasmine and Choudhari, Sonali Gajanan and Chowdhury, Enayet Karim and Chu, Dinh-Toi and Corso, Barbara and Dadras, Omid and Dai, Xiaochen and Damasceno, Albertino Antonio Moura and Dandona, Lalit and Dandona, Rakhi and Dávila-Cervantes, Claudio Alberto and De Neve, Jan-Walter and Denova-Gutiérrez, Edgar and Dhamnetiya, Deepak and Diaz, Daniel and Ebtehaj, Sanam and Edinur, Hisham Atan and Eftekharzadeh, Sahar and El Sayed, Iman and Elgendy, Islam Y and Elhadi, Muhammed and Elmonem, Mohamed A and Faisaluddin, Mohammed and Farooque, Umar and Feng, Xiaoqi and Fernandes, Eduarda and Fischer, Florian and Flood, David and Freitas, Marisa and Gaal, Peter Andras and Gad, Mohamed M and Gaewkhiew, Piyada and Getacher, Lemma and Ghafourifard, Mansour and Ghanei Gheshlagh, Reza and Ghashghaee, Ahmad and Ghith, Nermin and Ghozali, Ghozali and Gill, Paramjit Singh and Ginawi, Ibrahim Abdelmageed and Glushkova, Ekaterina Vladimirovna and Golechha, Mahaveer and Gopalani, Sameer Vali and Guimarães, Rafael Alves and Gupta, Rajat Das and Gupta, Rajeev and Gupta, Vivek Kumar and Gupta, Veer Bala and Gupta, Sapna and Habtewold, Tesfa Dejenie and Hafezi-Nejad, Nima and Halwani, Rabih and Hanif, Asif and Hankey, Graeme J and Haque, Shafiul and Hasaballah, Ahmed I and Hasan, Syed Shahzad and Hashi, Abdiwahab and Hassanipour, Soheil and Hay, Simon I and Hayat, Khezar and Heidari, Mohammad and Hossain, Mohammad Bellal Hossain and Hossain, Sahadat and Hosseini, Mostafa and Hoveidamanesh, Soodabeh and Huang, Junjie and Humayun, Ayesha and Hussain, Rabia and Hwang, Bing-Fang and Ibitoye, Segun Emmanuel and Ikuta, Kevin S and Inbaraj, Leeberk Raja and Iqbal, Usman and Islam, Md Shariful and Islam, Sheikh Mohammed Shariful and Islam, Rakibul M and Ismail, Nahlah Elkudssiah and Isola, Gaetano and Itumalla, Ramaiah and Iwagami, Masao and Iyamu, Ihoghosa Osamuyi and Jahani, Mohammad Ali and Jakovljevic, Mihajlo and Jayawardena, Ranil and Jha, Ravi Prakash and John, Oommen and Jonas, Jost B and Joo, Tamas and Kabir, Ali and Kalhor, Rohollah and Kamath, Ashwin and Kanchan, Tanuj and Kandel, Himal and Kapoor, Neeti and Kayode, Gbenga A and Kebede, Sewnet Adem and Keshavarz, Pedram and Keykhaei, Mohammad and Khader, Yousef Saleh and Khajuria, Himanshu and Khan, Moien AB and Khan, Md Nuruzzaman and Khan, Maseer and Khater, Amir M and Khoja, Tawfik Ahmed Muthafer and Khubchandani, Jagdish and Kim, Min Seo and Kim, Yun Jin and Kimokoti, Ruth W and Kisa, Sezer and Kisa, Adnan and Kivimäki, Mika and Korshunov, Vladimir Andreevich and Korzh, Oleksii and Koyanagi, Ai and Krishan, Kewal and Kuate Defo, Barthelemy and Kumar, G Anil and Kumar, Nithin and Kusuma, Dian and La Vecchia, Carlo and Lacey, Ben and Larsson, Anders O and Lasrado, Savita and Lee, Wei-Chen and Lee, Chiachi Bonnie and Lee, Paul H and Lee, Shaun Wen Huey and Li, Ming-Chieh and Lim, Stephen S and Lim, Lee-Ling and Lucchetti, Giancarlo and Majeed, Azeem and Malik, Ahmad Azam and Mansouri, Borhan and Mantovani, Lorenzo Giovanni and Martini, Santi and Mathur, Prashant and McAlinden, Colm and Mehedi, Nafiul and Mekonnen, Teferi and Menezes, Ritesh G and Mersha, Amanual Getnet and Miao Jonasson, Junmei and Miazgowski, Tomasz and Michalek, Irmina Maria and Mirica, Andreea and Mirrakhimov, Erkin M and Mirza, Agha Zeeshan and Mithra, Prasanna and Mohammadian-Hafshejani, Abdollah and Mohammadpourhodki, Reza and Mohammed, Arif and Mokdad, Ali H and Molokhia, Mariam and Monasta, Lorenzo and Moni, Mohammad Ali and Moradpour, Farhad and Moradzadeh, Rahmatollah and Mostafavi, Ebrahim and Mueller, Ulrich Otto and Murray, Christopher J L and Mustafa, Ahmad and Nagel, Gabriele and Nangia, Vinay and Naqvi, Atta Abbas and Nayak, Biswa Prakash and Nazari, Javad and Ndejjo, Rawlance and Negoi, Ruxandra Irina and Neupane Kandel, Sandhya and Nguyen, Cuong Tat and Nguyen, Huong Lan Thi and Noubiap, Jean Jacques and Nowak, Christoph and Oancea, Bogdan and Odukoya, Oluwakemi Ololade and Oguntade, Ayodipupo Sikiru and Ojo, Temitope T and Olagunju, Andrew T and Onwujekwe, Obinna E and Ortiz, Alberto and Owolabi, Mayowa O and Palladino, Raffaele and Panda-Jonas, Songhomitra and Pandi-Perumal, Seithikurippu R and Pardhan, Shahina and Parekh, Tarang and Parvizi, Mojtaba and Pepito, Veincent Christian Filipino and Perianayagam, Arokiasamy and Petcu, Ionela-Roxana and Pilania, Manju and Podder, Vivek and Polibin, Roman V and Postma, Maarten J and Prashant, Akila and Rabiee, Navid and Rabiee, Mohammad and Rahimi-Movaghar, Vafa and Rahman, Muhammad Aziz and Rahman, Md. Mosfequr and Rahman, Mosiur and Rahmawaty, Setyaningrum and Rajai, Nazanin and Ram, Pradhum and Rana, Juwel and Ranabhat, Kamal and Ranasinghe, Priyanga and Rao, Chythra R and Rao, Satish and Rawaf, Salman and Rawaf, David Laith and Rawal, Lal and Renzaho, Andre M N and Rezaei, Nima and Rezapour, Aziz and Riahi, Seyed Mohammad and Ribeiro, Daniela and Rodriguez, Jefferson Antonio Buendia and Roever, Leonardo and Rohloff, Peter and Rwegerera, Godfrey M and Ryan, Paul MacDaragh and Saber-Ayad, Maha Mohamed and Sabour, Siamak and Saddik, Basema and Saeedi Moghaddam, Sahar and Sahebkar, Amirhossein and Sahoo, Harihar and Saif-Ur-Rahman, KM and Salimzadeh, Hamideh and Samaei, Mehrnoosh and Sanabria, Juan and Santric-Milicevic, Milena M and Sathian, Brijesh and Sathish, Thirunavukkarasu and Schlaich, Markus P and Seidu, Abdul-Aziz and Šekerija, Mario and Senthil Kumar, Nachimuthu and Seylani, Allen and Shaikh, Masood Ali and Shamshad, Hina and Shawon, Md Shajedur Rahman and Sheikhbahaei, Sara and Shetty, Jeevan K and Shiri, Rahman and Shivakumar, K M and Shuval, Kerem and Singh, Jasvinder A and Singh, Ambrish and Skryabin, Valentin Yurievich and Skryabina, Anna Aleksandrovna and Sofi-Mahmudi, Ahmad and Soheili, Amin and Sun, Jing and Szerencsés, Viktória and Szócska, Miklós and Tabarés-Seisdedos, Rafael and Tadbiri, Hooman and Tadesse, Eyayou Girma and Tariqujjaman, Md. and Thankappan, Kavumpurathu Raman and Thapar, Rekha and Thomas, Nihal and Timalsina, Binod and Tobe-Gai, Ruoyan and Tonelli, Marcello and Tovani-Palone, Marcos Roberto and Tran, Bach Xuan and Tripathy, Jaya Prasad and Tudor Car, Lorainne and Tusa, Biruk Shalmeno and Uddin, Riaz and Upadhyay, Era and Valadan Tahbaz, Sahel and Valdez, Pascual R and Vasankari, Tommi Juhani and Verma, Madhur and Villalobos-Daniel, Victor E and Vladimirov, Sergey Konstantinovitch and Vo, Bay and Vu, Giang Thu and Vukovic, Rade and Waheed, Yasir and Wamai, Richard G and Werdecker, Andrea and Wickramasinghe, Nuwan Darshana and Winkler, Andrea Sylvia and Wubishet, Befikadu Legesse and Xu, Xiaoyue and Xu, Suowen and Yahyazadeh Jabbari, Seyed Hossein and Yatsuya, Hiroshi and Yaya, Sanni and Yazie, Taklo Simeneh Yazie and Yi, Siyan and Yonemoto, Naohiro and Yunusa, Ismaeel and Zadey, Siddhesh and Zaman, Sojib Bin and Zamanian, Maryam and Zamora, Nelson and Zastrozhin, Mikhail Sergeevich and Zastrozhina, Anasthasia and Zhang, Zhi-Jiang and Zhong, Chenwen and Zmaili, Mohammad and Zumla, Alimuddin and Naghavi, Mohsen and Schmidt, Maria Inês (2022) Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. The Lancet Diabetes & Endocrinology, 10 (3). pp. 177-192. ISSN 22138587

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Abstract

Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990-2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73.7% (68.3 to 77.4) were classified as due to type 1 diabetes. The age-standardised death rate was 0.50 (0.44 to 0.58) per 100 000 population, and 15 900 (97.5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0.13 (0.12 to 0.14) per 100 000 population in the high SDI quintile, 0.60 (0.51 to 0.70) per 100 000 population in the low-middle SDI quintile, and 0.71 (0.60 to 0.86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r(2)=0.62). From 1990 to 2019, age-standardised death rates decreased globally by 17.0% (-28.4 to -2.9) for all diabetes, and by 21.0% (-33.0 to -5.9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (-13.6% [-28.4 to 3.4]) and for type 1 diabetes (-13.6% [-29.3 to 8.9]). Interpretation Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations.

Item Type: Article
Subjects: WA Public Health > WA. 900 Vital Statistics
WD Nutrition Disease and metabolic diseases
Divisions: Reserach Vice-Chancellar Department > Community-Oriented Nursing Midwifery Research Center
Depositing User: zeynab . bagheri
Date Deposited: 01 Aug 2022 07:07
Last Modified: 01 Aug 2022 07:07
URI: http://eprints.skums.ac.ir/id/eprint/9590

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