T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses

Aleebrahim-Dehkordi, Elahe and Molavi, Bahareh and Mokhtari, Melika and Deravi, Niloofar and Fathi, Mobina and Fazel, Tara and Mohebalizadeh, Mehdi and Koochaki, Pooneh and Shobeiri, Parnian and Hasanpour-Dehkordi, Ali (2022) T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses. Transplant Immunology, 70. p. 101495. ISSN 09663274

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Official URL: http://doi.org/10.1016/j.trim.2021.101495

Abstract

Cytokines produced by T helper cells (Th cells) have essential roles in the body's defense against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in 2020 and is a serious threat to the public health. Pulmonary immunopathology is the leading cause of death during influenza and SARS-CoV-2 epidemics and pandemics. Influenza and SARS-CoV-2 cause high levels of cytokines in the lung. Both inadequate levels and high levels of specific cytokines can have side effects. In this literature review article, we want to compare the Th1 and Th2 cells responses in SARS-CoV-2 and H1N1.

Item Type: Article
Subjects: WC Communicable Diseases
WC Communicable Diseases > Virus diseases
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 12 Mar 2022 07:38
Last Modified: 12 Mar 2022 07:38
URI: http://eprints.skums.ac.ir/id/eprint/9472

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