Medicinal plants with anti-poisoning toxicity of carbon tetrachloride: An overview of the most important medicinal plants native to Iran with anti- carbon tetrachloride toxicity

Mahmoudi, Ghafar Ali. and Mahmoodnia, Leila. and Mirhosseini, Mahmoud. (2016) Medicinal plants with anti-poisoning toxicity of carbon tetrachloride: An overview of the most important medicinal plants native to Iran with anti- carbon tetrachloride toxicity. Journal of Global Pharma Technology, 8 (11). pp. 17-20.

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Abstract

One type of the liver poisoning is poisoning with carbon tetrachloride. Carbon tetrachlorideinduced liver damage is related to the toxic agent which is metabolized by the NADPH-cytochrome P450 enzyme system to reactive radicals including trikler and methyl- o- proxyler. One of the available remedies to protect liver is the use of medicinal plants. Since in Iran liver protective drugs are less available, then the use of available natural remedies that have fewer toxic side effects than chemical drugs seems necessary. In the present study, medicinal plants native to Iran have been reviewed and reported which have liver protective effect against toxicity induced by carbon tetrachloride as a factor causing human poisoning. In this review study, literatures were searched with key words including liver toxicity, carbon tetrachloride, herbs, extracts, and essential oils. The papers were searched from databases inside and outside Iran including Google Scholar, SID, MegaIran databases, and a number of other databases. Based on the results, medicinal herbs such as grape, oak, Aucheri, pistachio, Fumaria, and milk thistle are anti-poisoning plamts against carbon tetrachloride. Since the active ingredients of the mentioned plants have been specified in the phytochemical studies, then catechin, epi-catechins, epi-3-gallate catechin, mucilage, calheritrin, fumaric acid and an alkaloid called fumarinkoerist, and nitrose amine are probably the active ingredients against carbon tetrachloride poisoning. © 2009-2016, JGPT.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: Carbon tetrachloride, Herbs, Iran, Liver, Poisoning
Subjects: WD Nutrition Disease and metabolic diseases
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zahra bagheri .
Date Deposited: 11 Jul 2017 04:23
Last Modified: 11 Jun 2018 07:27
URI: http://eprints.skums.ac.ir/id/eprint/947

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