Phytopharmacology and phytotherapy of regulatory T cells: A new approach to treat multiple sclerosis

Mahmoudian Sani, Mohammad Reza. and Asadi-Samani, Majid. and Rouhi-Boroujeni, Hojjat. and Banitalebi Dehkordi, Mehdi. (2016) Phytopharmacology and phytotherapy of regulatory T cells: A new approach to treat multiple sclerosis. Der Pharmacia Lettre, 8 (3). pp. 215-220.


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Multiple sclerosis (MS) is a disorder of central nervous system characterized by demyelination, inflammation, and axonal injury. Regulatory T cells (Tregs) have been defined as CD4+CD25+FoxP3+ T-cells that play a critical role in maintaining self-tolerance and preventing autoimmune diseases. Dysfunction and decreased numbers of Tregs may lead to MS. Web of Science and PubMed databases were searched using the Endnote software for the publications about the role of Tregs in MS published from 2000 to February 2016. The medicinal plants and their derivatives, including Hypericum perforatum, Astragalus membranaceus, Pterodon emarginatus Vogel, curcumin, resveratrol, matrine, Bu Shen Yi Sui Capsule, and Hyungbangpaedok-san have been reported to regulate the function of Tregs in MS. The medicinal plants and their derivatives reported in this study might be useful for upregulation of Tregs through suppressing the activation of autoreactive T cells and hence controlling MS. They should be investigated in clinical trials to help to prevent and treat MS.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: Herbal drugs, Medicinal plants, Multiple sclerosis, Phytochemicals, Regulatory T cells
Subjects: WL Nervous system
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > student research center
Depositing User: Users 1 not found.
Date Deposited: 11 Jul 2017 03:45
Last Modified: 03 Jun 2018 04:04

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