Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression

Farhat, Ahmadshah and Ferns, Gordon A. and Ashrafi, Korosh and Arjmand, Mohammad-Hassan (2020) Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression. Gastrointestinal Tumors, 8 (1). pp. 33-40. ISSN 2296-3774

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Abstract

Background: Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the association between Lox activity and the progression of GI cancers. Lox proteins are a group of extracellular enzymes that catalyzed the cross-linking of collagen and elastin, so they have important roles in the control of structure and homeostasis of ECM. Abnormal activation and expression of the Lox family of proteins lead to changes in the ECM toward increased rigidity and fibrosis. Stiffness of ECM can contribute to the pathogenesis of cancers. Summary: Dysregulation of Lox expression is a factor in both fibrotic diseases and cancer. ECM stiffness by Lox overactivity creates a physical barrier against intratumoral concentration of chemotherapeutic drugs and facilitates cancer inflammation, angiogenesis, and metastasis. Key message: Because of the roles of Lox in GI cancers, development targeting Lox protein isotypes may be an appropriate strategy for treatment of GI cancers and improvement in survival of patients. Keywords: Angiogenesis; Extracellular matrix stiffness; Gastrointestinal malignancies; Inflammation; Lysyl oxidase

Item Type: Article
Subjects: WI Digestive System
QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 20 Feb 2022 05:19
Last Modified: 20 Feb 2022 05:19
URI: http://eprints.skums.ac.ir/id/eprint/9387

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