Chlorella vulgaris supplementation attenuates the progression of liver fibrosis through targeting TGF-β-signaling pathway in the CCl4-induced liver fibrosis in rats

Mohseni, Roohollah and Arab Sadeghabadi, Zahra and Karimi, Jamshid and Gholami, Hamid and Ghasemi, Hadi and Ghadimipour, Hamid Reza and Kheiripour, Nejat (2021) Chlorella vulgaris supplementation attenuates the progression of liver fibrosis through targeting TGF-β-signaling pathway in the CCl4-induced liver fibrosis in rats. Toxin Reviews, 40 (4). pp. 1347-1355. ISSN 1556-9543

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Abstract

The purpose of this study is to investigate the molecular mechanism underlying hepatoprotective effect of Chlorella vulgaris extract (CVE). The administration of both doses of CVE attenuated liver damage and decreased serum markers and oxidative stress parameters dramatically. Also, CVE treatment downregulated hepatic gene expression of collagen type1 (Col1a1), fibronectin (Fn1), transforming growth factor-beta 1 (Tgfb1), transforming growth factor-beta receptor 2 (Tgfbr2) and SMAD family member 3 (Smad3) significantly. Hepatic level of TGF-β1 protein was decreased by CVE treatment significantly. CVE supplementation restraints liver fibrosis progression through amelioration of oxidative stress status and targeting TGF-β signaling pathway

Item Type: Article
Subjects: QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zeynab . bagheri
Date Deposited: 16 Feb 2022 06:35
Last Modified: 16 Feb 2022 06:35
URI: http://eprints.skums.ac.ir/id/eprint/9371

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