Calcitonin receptor AluI (rs1801197) and TaqI calcitonin genes polymorphism in 45-and over 45-year-old women and their association with bone density

Dehghan, M. and Pourahmad-Jaktaji, R. and Farzaneh, Z. (2016) Calcitonin receptor AluI (rs1801197) and TaqI calcitonin genes polymorphism in 45-and over 45-year-old women and their association with bone density. Acta Informatica Medica, 24 (4). pp. 239-243.

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Abstract

Purpose: Calcitonin receptor gene has also a polymorphism which is associated with bone mass density. This study evaluates the association between calcitonin receptor AluI (rs1801197) and Taq1 calcitonin genes polymorphism with bone density rate. Methods: In this descriptive-analytical study in 2013 in southwestern Iran, 200 blood samples, per the Cochran sample size formula, were taken from women aged 45 and older. DNA was extracted from the samples using the phenol- chloroform method and the genomic fragments in question were proliferated using the polymerase chain reaction (PCR) method. Results: The genotypic distribution of polymorphism AluI for TT, TC, and CC genotypes in control group was 31.4%, 38.6%, and 30% and in patients 25.4%, 55.4%, and 19.2%, respectively. There was no significant difference in polymorphism AluI between patients and control group and no significant association was found between this gene and bone density rate (P > 0.05). All patients and the individuals in the control group exhibited tt genotype for TaqI calcitonin gene and no significant association was found between these participants and osteoporosis. Conclusion: There was no association between two polymorphisms and osteoporosis, and between polymorphism of these two genes and osteoporosis development rate in the participants. © 2016 Morteza Dehghan, Razieh Pourahmad-Jaktaji, and Zarghampoor Farzaneh.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: AluI calcitonin receptor gene, Osteoporosis, Polymorphism, TaqI calcitonin gene
Subjects: WE Musculoskeletal system
QU Biochemistry
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Orthopedics
Depositing User: zahra bagheri .
Date Deposited: 11 Jul 2017 03:21
Last Modified: 11 Jul 2017 03:21
URI: http://eprints.skums.ac.ir/id/eprint/936

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