Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Wu, Ai-Min and Bisignano, Catherine and James, Spencer L. and Abady, Gdiom Gebreheat and Abedi, Aidin and Abu-Gharbieh, Eman and Alhassan, Robert Kaba and Alipour, Vahid and Arabloo, Jalal and Asaad, Malke and Asmare, Wondwossen Niguse and Awedew, Atalel Fentahun and Banach, Maciej and Banerjee, Srikanta K. and Bijani, Ali and Birhanu, Tesega Tesega Mengistu and Bolla, Srinivasa Rao and Camera, Luis Alberto and Chang, Jung-Chen and Cho, Daniel Youngwhan and Chung, Michael T. and Couto, Rosa A. S. and Dai, Xiaochen and Dandona, Lalit and Dandona, Rakhi and Farzadfar, Farshad and Filip, Irina and Fischer, Florian and Fomenkov, Artem Alekseevich and Gill, Tiffany K. and Gupta, Bhawna and Haagsma, Juanita A. and Haj-Mirzaian, Arvin and Hamidi, Samer and Hay, Simon and Ilic, Irena M. and Ilic, Milena D. and Ivers, Rebecca Q. and Jurisson, Mikk and Kalhor, Rohollah and Kanchan, Tanuj and Kavetskyy, Taras and Khalilov, Rovshan and Khan, Ejaz Ahmad and Khan, Maseer and Kneib, Cameron J. and Krishnamoorthy, Vijay and Kumar, G. Anil and Kumar, Narinder and Lalloo, Ratilal and Lasrado, Savita and Lim, Stephen S. and Liu, Zichen and Manafi, Ali and Manafi, Navid and Menezes, Ritesh G. and Meretoja, Tuomo J. and Miazgowski, Bartosz and Miller, Ted R. and Mohammad, Yousef and Mohammadian-Hafshejani, Abdollah and Mokdad, Ali H. and Murray, Christopher J. L. and Naderi, Mehdi and Naimzada, Mukhammad David and Nayak, Vinod C. and Nguyen, Cuong Tat and Nikbakhsh, Rajan and Olagunju, Andrew T. and Otstavnov, Nikita and Otstavnov, Stanislav S. and Padubidri, Jagadish Rao and Pereira, Jeevan and Pham, Hai Quang and Pinheiro, Marina and Polinder, Suzanne and Pourchamani, Hadis and Rabiee, Navid and Radfar, Amir and Rahman, Mohammad Hifz Ur and Rawaf, David Laith and Rawaf, Salman and Saeb, Mohammad Reza and Samy, Abdallah M. and Riera, Lidia Sanchez and Schwebel, David C. and Shahabi, Saeed and Shaikh, Masood Ali and Soheili, Amin and Tabares-Seisdedos, Rafael and Tovani-Palone, Marcos Roberto and Tran, Bach Xuan and Travillian, Ravensara S. and Valdez, Pascual R. and Vasankari, Tommi Juhani and Velazquez, Diana Zuleika and Venketasubramanian, Narayanaswamy and Vu, Giang Thu and Zhang, Zhi-Jiang and Vos, Theo and Collaborators, GBD 2019 Fracture (2021) Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. LANCET HEALTHY LONGEVITY, 2 (9). E580-E592.

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Background Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings Globally, in 2019, there were 178 million (95% UI 162-196) new fractures (an increase of 33.4% 30.1-37.0] since 1990), 455 million (428-484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70.1% 67.5-72.5] since 1990), and 25.8 million (17.8-35.8) YLDs (an increase of 65.3% 62.4-68.0] since 1990). The age-standardised rates of fractures in 2019 were 2296.2 incident cases (2091.1-2529.5) per 100 000 population (a decrease of 9.6% 8.1-11.1] since 1990), 5614.3 prevalent cases (5286.1-5977.5) per 100 000 population (a decrease of 6.7% 5.7-7.6] since 1990), and 319.0 YLDs (220.1-442.5) per 100 000 population (a decrease of 8.4% 7.2-9.5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419.9 cases (345.8-512.0) per 100 000 population and an age-standardised rate of YLDs of 190.4 (125.0-276.9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381.5 incident cases (11 245.3-20 651.9) per 100 000 population in those aged 95 years and older. Interpretation The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.

Item Type: Article
Subjects: WA Public Health > WA. 900 Vital Statistics
WE Musculoskeletal system
Divisions: Faculty of Health > Department of Epidemiology
Depositing User: zeynab . bagheri
Date Deposited: 08 Jan 2022 10:57
Last Modified: 08 Jan 2022 10:57

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