Preventive effect of Silybum marianum hydroalcoholic extract on post-surgical intra-abdominal adhesion in rats

Asadi, Seyed Yazdan. and Parsaei, Pouya. and Shafiei Alavijeh, Soheil. and Rafieian-Kopaei, Mahmoud. and Karimi, Mehrdad. (2016) Preventive effect of Silybum marianum hydroalcoholic extract on post-surgical intra-abdominal adhesion in rats. Journal of Zanjan University of Medical Sciences and Health Services, 24 (102). pp. 32-43.


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Adhesion formation is the commonest complication of abdominal surgery. Bearing an anti-oxidant activity, Silybum marianum may reduce adhesion formation. This study was an endeavor to shed light on the effect of Silybum marianum on intra-abdominal adhesions. Materials and Methods: In this experimental study, 30 rats were randomly assigned to three groups: treated by 1% and 5% concentrations of the S. marianum extract (groups A and B) and distillated water (group C). After laparotomy, three longitudinal and transverse incisions (2 cm in length) were made on the right wall of the abdomen and a 2×2 piece was removed from peritoneal surface on the left side of the abdominal wall. In groups A, B and C, 3 mL of 1% and 5% of S. marianum extract or distillated water were administered into abdominal cavity of the rats, respectively. After 14 days, adhesion degrees were determined according to the number of adhesion bands (Canbaz scale). Data analysis was performed through SPSS 16 using Kruskal-Wallis and Mann-Whitney tests. Results: There was a significant difference in adhesion formation among the groups (P=0.023). Adhesion degree in groups A and B were significantly lower than the control group (P<0.05). Conclusion: S. marianum extract supported a preventive effect on intra-abdominal adhesion in rats, which gives rise to the evidence that it may be similarly effective for human cases. Throughout further clinical studies, this plant and its derived compounds might be applied in the treatment of such complications subsequent to abdominal surgeries.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Intra-abdominal adhesion, Rat ,Silybum marianum
Subjects: WO Surgery
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Surgery
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 10 Jul 2017 07:13
Last Modified: 30 May 2018 03:45

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