Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes

Abpeikar, Zahra and Milan, Peiman Brouki and Moradi, Lida and Anjomshoa, Maryam and Asadpour, Shiva (2021) Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes. MECHANICS OF ADVANCED MATERIALS AND STRUCTURES. ISSN 1537-6494

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Abstract

Articular cartilage has weak intrinsic self-healing capacity. Tissue engineering is an appropriate option for cartilage regeneration. This research was designed to evaluate the effects of pore size in scaffolds on mechanical properties and chondrocyte-scaffold interactions. PCL scaffolds were fabricated with large, medium, and small pore sizes. The constructs were analyzed by SEM, swelling tests, mechanical tests, MTT assay, and H&E staining after chondrocyte seeding. Mechanical features of the scaffolds were near to human articular cartilage. Our findings suggest that the PCL scaffold with medium pore sizes provides suitable mechanical strength and better chondrocyte-scaffold interactions simultaneously for application in cartilage.

Item Type: Article
Subjects: QS Human Anatomy
QS Human Anatomy
university Structure > QS Human Anatomy

WE Musculoskeletal system
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Depositing User: zeynab . bagheri
Date Deposited: 11 Sep 2021 05:16
Last Modified: 11 Sep 2021 05:16
URI: http://eprints.skums.ac.ir/id/eprint/9166

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