Butylcycloheptylprodigiosin and undecylprodigiosin are potential photosensitizer candidates for photodynamic cancer therapy

Arshadi, Zahra and Hosseini, Sayedeh Azimeh and Fatehi, Daryoush and Mirzaei, Seyed Abbas and Elahian, Fatemeh (2021) Butylcycloheptylprodigiosin and undecylprodigiosin are potential photosensitizer candidates for photodynamic cancer therapy. MOLECULAR BIOLOGY REPORTS, 48 (8). pp. 5965-5975. ISSN 0301-4851

Full text not available from this repository.

Abstract

Background Prodiginines are bacterial red polypyrrole pigments and multifaceted secondary metabolites. These agents have anti-proliferative, immunosuppressive, antimicrobial, and anticancer effects. Recent analysis revealed that prodigiosin hypersensitizes Serratia marcescens to gamma radiation. In the present study, we report the cytotoxicity and genotoxicity properties of undecylprodigiosin and butylcycloheptylprodigiosin in the presence and absence of radiation through the MTT and alkaline comet experiments. Methods and results Findings demonstrated that undecylprodigiosin was at least a fivefold more cytotoxic at low radiation doses (1 and 3 Gy) on both MCF7 and HDF lines rather than in the absence or high radiation doses (5 Gy) (P value < 0.05). Although butylcycloheptylprodigiosin toxicity on MCF7 and HDF was dose-dependent, it was not influenced by any radiation doses (P value > 0.05). Comet findings confirmed that these compounds' genotoxicity is only dose-dependent. Radiation had no significant effects on DNA damage on any of the cells (P value > 0.05). Conclusions In general, it can be concluded that the prodiginines are cytotoxic agents that act as a double-edged sword, radiosensitizers and radio-protective, respectively at low and high radiation doses in cancer treatment process. As the results they could be used in antitumor therapies very soon.

Item Type: Article
Subjects: QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Advanced Technologies > Department of Medical Biotechnology
Depositing User: zeynab . bagheri
Date Deposited: 06 Sep 2021 05:57
Last Modified: 06 Sep 2021 05:57
URI: http://eprints.skums.ac.ir/id/eprint/9132

Actions (login required)

View Item View Item