Association between a genetic variant in scavenger receptor class B type 1 and its role on codon usage bias with increased risk of developing coronary artery disease

Sahebi, Reza and Ghazizadeh, Hamideh and Avan, Amir and Tayefi, Maryam and Saffar-Soflaei, Sara and Mouhebati, Mohsen and Esmaily, Habibollah and Ferns, Gordon A. and Hashemzadeh-Chaleshtori, Morteza and Ghayour-Mobarhan, Majid and Farrokhi, Effat (2021) Association between a genetic variant in scavenger receptor class B type 1 and its role on codon usage bias with increased risk of developing coronary artery disease. CLINICAL BIOCHEMISTRY, 95. pp. 60-65. ISSN 0009-9120

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Abstract

Objective: Coronary artery disease (CAD) as an important cause of morbidity and mortality globally. The scavenger receptor class B type 1 (SCARB1) plays an essential role in the reverse cholesterol transport. We have explored the association between a genetic variant, rs5888, in the SCARB1 gene with CAD and serum HDL-C levels. Methods: Patients were categorized into two groups' angiogram positive (>50% coronary stenosis) and angiogram negative (<50% coronary stenosis). Genotyping was carried out using polymerase chain reaction amplification refractory mutation system. The association between the SNP rs5888 and serum HDL-C was analyzed using a logistic regression model. Results: The results showed that the subjects carrying a T allele was associated with a decreased serum HDL-C levels compared to the C allele in total population (p < 0.001). The risk of angiogram positivity in subjects carrying a T allele was 3.1-fold higher than for the control group (p < 0.001). Conclusion: CVD patients carrying the T allele of rs5888 variant in the SCARB1 gene was associated with decreased serum level of HDL.

Item Type: Article
Uncontrolled Keywords: Rs5888; Coronary artery disease; SCARB1; Risk factor; Genotyping; RCSU
Subjects: WG Cardiovascular System
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Advanced Technologies > Department of Molecular Medicine
Depositing User: zeynab . bagheri
Date Deposited: 04 Sep 2021 08:49
Last Modified: 04 Sep 2021 08:49
URI: http://eprints.skums.ac.ir/id/eprint/9116

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