Interaction between the genetic variant of rs696217-ghrelin and food intake and obesity and dyslipidemia

Yadegari, Mehran and Zare-Feyzabadi, Reza and Zakariaeiseraji, Mohanna and Sahebi, Reza and Shabani, Niloofar and Khedmatgozar, Hamed and Ferns, Gordon A. and Ghazizadeh, Hamideh and Mohammadi-Bajgiran, Maryam and Jalalian, Melika and Zoghi, Mohadese and Darban, Reza Assaran and Mohammadian-Ghosooni, Mahdi and Esmaily, Habibollah and Avan, Amir and Ghayour-Mobarhan, Majid (2021) Interaction between the genetic variant of rs696217-ghrelin and food intake and obesity and dyslipidemia. ANNALS OF HUMAN GENETICS. ISSN 0003-4800

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Abstract

In this study, we aimed to investigate the relationship between the genetic variant of rs696217-ghrelin and fasted lipid profile, indices of obesity, and environmental parameters. Amplification refractory mutation system-polymerase chain reaction (ARMs-PCR) was used for genotyping 1118 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction between the presence of the genetic variant of rs696217-ghrelin and nutritional intake and other major determinants of obesity and lipid profile was examined in the MASHAD study population. Individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among the individuals. No significant relationship was found between the two groups regarding the lipid profile and TT genotype. Furthermore, no significant association was found between dietary intake and the genetic variant of rs696217-ghrelin in the population under study. Individuals with a TT or GT genotype appear to be at a higher risk of obesity, compared to those with a GG genotype. The results of the current study revealed a significant association between the genetic variant of rs696217-ghrelin and obesity; however, this gene did not correlate with the risk factors of cardiovascular diseases and dyslipidemia in the Iranian population.

Item Type: Article
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Advanced Technologies > Department of Molecular Medicine
Depositing User: zeynab . bagheri
Date Deposited: 04 Sep 2021 03:49
Last Modified: 04 Sep 2021 03:49
URI: http://eprints.skums.ac.ir/id/eprint/9107

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