Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development

Kiaie, Seyed Hossein and Sanaei, Mohammad Javad and Heshmati, Masoud and Asadzadeh, Zahra and Azimi, Iman and Hadidi, Saleh and Jafari, Reza and Baradaran, Behzad (2021) Immune checkpoints in targeted-immunotherapy of pancreatic cancer: New hope for clinical development. Acta Pharmaceutica Sinica B. ISSN 22113835

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Abstract

Immunotherapy has been recently considered as a promising alternative for cancer treatment. Indeed, targeting of immune checkpoint (ICP) strategies have shown significant success in human malignancies. However, despite remarkable success of cancer immunotherapy in pancreatic cancer (PCa), many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus far. In this process, immunosuppression in the tumor microenvironment (TME) is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy method. In this paper, the latest findings on the ICPs, which mediate immunosuppression in the TME have been reviewed. In addition, different approaches for targeting ICPs in the TME of PCa have been discussed. This review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa.

Item Type: Article
Additional Information: cited By 0
Subjects: QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zeynab . bagheri
Date Deposited: 07 Jun 2021 08:43
Last Modified: 07 Jun 2021 08:43
URI: http://eprints.skums.ac.ir/id/eprint/9085

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