Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil

Elahian, Fatemeh and Garshasbi, Maryam and Asiabar, Zahra Mehri and Dehkordi, Neda Gholamian and Yazdinezhad, Alireza and Mirzaei, Seyed Abbas (2021) Ecotypic Variations Affected the Biological Effectiveness of Thymus daenensis Celak Essential Oil. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (668655). ISSN 1741-427X

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Abstract

Thymus (Lamiaceae) is famous for its pharmacological properties. Thymus daenensis Celak (Avishan-e-denaee in Persian) is an endemic Thymus species in Iran and is traditionally used for its digestive, carminative, antitussive, antispasmodic, and expectorant attributes in folk medicine. Ecotypic oils were extracted and analyzed with the GC-MS. Their biological properties in terms of antimicrobial, antioxidant, and antigenotoxic activities were evaluated using the minimal inhibitory concentration, minimal bactericidal concentration, and DPPH, beta-carotene, and comet assays. The GC-MS results for Thymus daenensis Celak oils revealed thymol (73.86%) and carvacrol (51.89%) as the most abundant components. Due to the results, reasonable bactericidal activity values range from 0.14 to 5.00 mg/ml, and fungicidal activity ranges from 0.17 to 0.58 mg/ml. The necessary oil free radical scavenging capacity (0.41-1.79 mg/ml), bleaching inhibitory activity (0.01-1.06 mg/ml), and genoprotective potential (1.04-7.78 mg/ml) indicated the dose-dependent activity. The results suggest that Thymus daenensis is an important antibacterial and antifungal bioresource. Additionally, the antioxidant and radical scavenging capacity suggests this species has a role as a natural preservative in oxidative diseases and in the prevention of food spoilage.

Item Type: Article
Subjects: QU Biochemistry > Cell biology and genetics
QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Faculty of Advanced Technologies > Department of Medical Biotechnology
Depositing User: zeynab . bagheri
Date Deposited: 01 Jun 2021 06:37
Last Modified: 01 Jun 2021 06:37
URI: http://eprints.skums.ac.ir/id/eprint/9056

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