Effect of White Tea (Camellia sinensis) Extract on Skin Wound Healing Process in Rats

Kouhihabibidehkordi, Golnoush and Kheiri, Soleiman and Karimi, Iraj and Taheri, Fatemeh and Bijad, Elham and Bahadoram, Mohammad and Alibabaie, Zahra and Asgharian, Shirin and Zamani, Hajar and Rafieian-Kopaei, Mahmoud (2021) Effect of White Tea (Camellia sinensis) Extract on Skin Wound Healing Process in Rats. WORLD JOURNAL OF PLASTIC SURGERY, 10 (1). pp. 85-95.

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BACKGROUND White tea (Camellia sinensis) has anti-inflammatory and antioxidant properties and a protective effect against wrinkles, sunburn and UV damages on the skin. Thus, we aimed to evaluate the effect of white tea extract on the healing process of skin wounds in rats. METHODS This study was done in the Research Center of Shahrekord University of Medical Sciences, Shahrekord, Iran in 2019. Excisional skin wounds were created on five groups of healthy male Wistar rats (200-250 g, n=21) including control group, Eucerin-treated group, white tea 5% ointment (Eucerin) treated group, gel-treated group, white tea 5% gel treated group. Treatment was begun on day 1 and repeated every day at the same time until day 15. Pathologic samples were taken on days 4, 7 and 15 for histopathological examinations. Kruskal-Wallis test was used to analyze data by SPSS. Statistical significance was defined as P<0.05. RESULTS Wound closure rate of control group was more than other groups on day 4 (P<0.05). On day 7, reepithelisation and granulation tissue of control group were more than white tea 5% ointment-treated and its inflammation was less than others (P<0.05). Neo-vascularization of white tea 5% ointment-treated group was more than control group on days 4 and 15 (P<0.05). On day 4, intact mast cells of control group were more than white tea treated groups (P<0.05). Degranulated mast cells of white tea 5% gel treated group was significantly (P<0.05) more than control group on days 4 and 15. CONCLUSION Five percent white tea extract could not help the skin wound healing process.

Item Type: Article
Uncontrolled Keywords: Antioxidant; Camellia sinensis; Cutaneous wound; Healing process; White tea
Subjects: QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 01 Jun 2021 04:06
Last Modified: 01 Jun 2021 04:06
URI: http://eprints.skums.ac.ir/id/eprint/9054

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