The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin II Type 1 Receptors: Need for Novel Treatment Strategies

Tavakkoli, Mahmood and Aali, Saeed and Khaledifar, Borzoo and Ferns, Gordon A. and Khazaei, Majid and Fekri, Kiavash and Arjmand, Mohammad-Hassan (2021) The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin II Type 1 Receptors: Need for Novel Treatment Strategies. GASTROINTESTINAL TUMORS.

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Abstract

Background: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor beta. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions. Summary: Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem. Key Message: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.

Item Type: Article
Subjects: WO Surgery
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Urology
Depositing User: zeynab . bagheri
Date Deposited: 31 May 2021 06:33
Last Modified: 31 May 2021 06:33
URI: http://eprints.skums.ac.ir/id/eprint/9037

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