Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

Hosseini, Alireza and Shahrani, Mehrdad and Asgharian, Shirin and Anjomshoa, Maryam and Rostamzadeh, Ayoob and Lorigooini, Zahra and Asgharzadeh, Najmeh and Azari, Abbas (2021) Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice. FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 7 (1).

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Abstract

Background: Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results: CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion: A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.

Item Type: Article
Uncontrolled Keywords: Allium atroviolaceum L.; Infertility; Cyclophosphamide; Spermatogenesis
Subjects: WJ Urogenital System
QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 31 May 2021 06:15
Last Modified: 31 May 2021 06:15
URI: http://eprints.skums.ac.ir/id/eprint/9035

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