Abpeikar, Zahra and Mohseni, Roohollah and Safaei, Mohsen (2021) The multifunctional nano-immunoliposome design: hypothesis on a therapeutic approach for COVID-19. TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, 103 (1). pp. 118-124. ISSN 0277-2248
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The multifunctional nano immunoliposome design hypothesis on a therapeutic approach for COVID 19.pdf - Published Version Download (1MB) |
Abstract
The article presents a hypothesis on a co-delivery strategy to suppress or reduce infection caused by the COVID-19 virus. Co-delivery was illustrated in many diseases, and results showed that it produced a high therapeutic efficacy against disorders. We proposed an approach to suppress or reduce infection caused by the coronavirus disease 2019 via designing an intelligent nano-liposome loaded with interferon gamma, interleukin 4 and small interfering RNA against vimentin. At the surface of this nanostructure, there is a matrix metallopeptidase3 substrate to provide a platform for the enzymatic function of matrix metallopeptidase3 to destroy the extracellular matrix, angiotensin-converting enzyme 2 blocker, and antibody against vimentin for targeting, trans-activator of transcription peptide, and polyethylene glycol. Due to the increasing application of nano-liposomes commercially as a drug-delivery system, it is important to consider this effective approach for the coronavirus disease 2019 treatment.
Item Type: | Article |
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Uncontrolled Keywords: | COVID-19; nano-immunoliposome; ACE2; interferon; vimentin |
Subjects: | QU Biochemistry > Cell biology and genetics |
Divisions: | Faculty of Advanced Technologies > Department of Tissue Engineering |
Depositing User: | zeynab . bagheri |
Date Deposited: | 31 May 2021 06:07 |
Last Modified: | 31 May 2021 06:07 |
URI: | http://eprints.skums.ac.ir/id/eprint/9033 |
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