Therapeutic potential of active components of saffron in post-surgical adhesion band formation

Arjmand, Mohammad-Hassan and Hashemzehi, Milad and Soleimani, Atena and Asgharzadeh, Fereshteh and Avan, Amir and Mehraban, Saeedeh and Fakhraei, Maryam and Ferns, Gordon A. and Ryzhikov, Mikhail and Gharib, Masoumeh and Salari, Roshanak and Sayyed Hoseinian, Sayyed Hadi and Parizadeh, Mohammad Reza and Khazaei, Majid and Hassanian, Seyed Mahdi (2021) Therapeutic potential of active components of saffron in post-surgical adhesion band formation. Journal of Traditional and Complementary Medicine. ISSN 22254110

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Background: Abdominal adhesions are common and often develop after abdominal surgery. There are currently no useful targeted pharmacotherapies for adhesive disease. Saffron and its active constituents, Crocin and Crocetin, are wildly used in traditional medicine for alleviating the severity of inflammatory or malignant disease. Purpose: The aim of this study was to investigate the therapeutic potential of the pharmacological active component of saffron in attenuating the formation of post-operative adhesion bands using different administration methods in a murine model. Material method: saffron extract (100 mg/kg), Crocin (100 mg/kg), and Crocetin (100 mg/kg) were administered intraperitoneally and by gavage in various groups of male Wistar rat post-surgery. Also three groups were first treated intra-peritoneally by saffron extract, Crocin, and Crocetin (100 mg/kg) for 10 days and then had surgery. At the end of the experiments, animals sacrificed for biological assessment. Result: A hydro-alcoholic extract of saffron and crocin but not crocetin potently reduced the adhesion band frequency in treatment and pre-treatment groups in the mice given intra-peritoneal (i.p) injections. Following the saffron or crocin administration, histological evaluation and quantitative analysis represented less inflammatory cell infiltration and less collagen composition, compared to control group. Moreover, the oxidative stress was significantly reduced in treatment groups. Conclusion: These findings suggest that a hydro-alcoholic extract of saffron or its active compound, crocin, is a potentially novel therapeutic strategy for the prevention of adhesions formation and might be used as beneficial anti-inflammatory or anti-fibrosis agents in clinical trials. Taxonomy: Abdominal surgeries/post-surgical adhesions. © 2021 Center for Food and Biomolecules, National Taiwan University

Item Type: Article
Additional Information: cited By 0
Subjects: WO Surgery
QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 13 Mar 2021 05:04
Last Modified: 13 Mar 2021 05:04

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