The association of vitamin D levels and insulin resistance

Ehrampoush, Elham and Mirzay Razzaz, Jalaledin and arjmand, Hossein and Ghaemi, Alireza and Raeisi Shahraki, Hadi and Ebrahim Babaei, Amirali and Osati, Saeed and Homayounfar, Reza (2021) The association of vitamin D levels and insulin resistance. Clinical Nutrition ESPEN. ISSN 24054577

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Objective: Vitamin D deficiency and insulin resistance have great prevalence in society. The latest studies indicate an inverse association between Vitamin D levels, insulin resistance, and Type 2 diabetes. The objective of this study was to investigate the effect of vitamin D status on insulin resistance. Methods: In a cross-sectional study, 2160 participants were randomly recruited from a nutrition clinic in Tehran, Iran, 1057 (48.9) were female and 1103 (51.1) male. Information was gathered by a questionnaire. Following 12-h fasting, fasting plasma glucose (FPG) and insulin levels, as well as 25-hydroxy vitamin D levels were measured. 2-H glucose and insulin levels measured after consumption of 75 g glucose, HOMA2-IR, and HOMA-β indices were then calculated. Results: The average serum Vitamin D was 22.3 + 8.9 nmol/L and the prevalence of Vitamin D deficiency was 100. There was an inverse relationship between Vitamin D levels and age, BMI, waist circumference, and all metabolic parameters (p < 0.001 in all) and a direct association with levels of exercise. Two logistic regression models were used to adjust for confounding variables; firstly, for age, gender, and smoking and secondly, additionally for BMI and energy intake. Both models showed a significant inverse relationship between Vitamin D levels and FPG and insulin levels, 2-h glucose and insulin levels, and HOMA2-IR. The optimum cut point for vitamin D was calculated at about 25 nmol/L for preventing insulin resistance. Conclusion: This study illustrated that there is a statistically significant inverse relationship between Vitamin D levels and insulin resistance. © 2021 European Society for Clinical Nutrition and Metabolism

Item Type: Article
Additional Information: cited By 0
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry > Nutrition.vitamins
Divisions: Faculty of Health > Department of Epidemiology
Depositing User: zeynab . bagheri
Date Deposited: 13 Mar 2021 08:21
Last Modified: 13 Mar 2021 08:21

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