Association of vitamin D status with liver and kidney disease: A systematic review of clinical trials, and cross-sectional and cohort studies

Parizadeh, Seyed Mostafa J and Rezayi, Majid and Jafarzadeh-Esfehani, Reza and Avan, Amir and Ghazizadeh, Hamideh and Emadzadeh, Maryam and Sahebi, Reza and Ferns, Gordon Ashley Anthony and Ghayour-Mobarhan, Majid (2021) Association of vitamin D status with liver and kidney disease: A systematic review of clinical trials, and cross-sectional and cohort studies. International Journal for Vitamin and Nutrition Research, 91 (1-2). pp. 175-187. ISSN 03009831

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Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4 in Isfahan to 98 in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: acute phase protein; aminotransferase; bilirubin; biochemical marker; C reactive protein; calcitriol; calcium; calcium carbonate; cholesterol; glucose; hemoglobin; high density lipoprotein; lipid; low density lipoprotein; protein A; triacylglycerol; vitamin D; vitamin; vitamin D, body mass; bone metabolism; calcium blood level; cholestasis; cholesterol blood level; clinical trial (topic); cytomegalovirus infection; dietary intake; disease association; enzyme linked immunosorbent assay; fatty liver; glucose blood level; glucose metabolism; Helicobacter infection; hemodialysis; hemoglobin blood level; hepatitis; HOMA index; human; international normalized ratio; kidney disease; lipid fingerprinting; liver cirrhosis; liver disease; liver function; liver function test; liver graft; neutrophil lymphocyte ratio; peritoneal dialysis; Review; sex difference; sleep quality; stone formation; study; systematic review; triacylglycerol blood level; vitamin blood level; vitamin D deficiency; vitamin intake; vitamin supplementation; complication; Iran; liver; vitamin D deficiency, Humans; Iran; Kidney Diseases; Liver; Vitamin D; Vitamin D Deficiency; Vitamins
Subjects: WJ Urogenital System
QU Biochemistry > Nutrition.vitamins
Divisions: Faculty of Advanced Technologies > Department of Molecular Medicine
Depositing User: zeynab . bagheri
Date Deposited: 28 Mar 2021 04:54
Last Modified: 28 Mar 2021 04:54

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