Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis

Sadeghi, Hamid Reza and Pirayesh, Ashkan and Shahsavan, Shaghayegh and Amani, Soroush and Amini, Sayed Asadollah and Ghatreh Samani, Keyhan and Deris, Fatemeh (2020) Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis. Central-European journal of immunology, 45 (3). pp. 294-300. ISSN 1426-3912

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Abstract

Aim of the study: To assess the level of acidic mammalian chitinase (AMCase) expression and IL-8 in nasal inferior turbinate mucosa in patients with mild and moderate to severe allergic rhinitis (AR). Material and methods: Participants in this case-control study were divided into three groups, including patients with moderate and severe persistent allergic rhinitis, cases with mild forms of persistent AR, and control or healthy group. We obtained biopsies of nasal inferior turbinate mucosa from all participants. Expression of AMCase and IL-8 mRNAs were evaluated by real-time polymerase chain reaction (PCR). The serum levels of AMCase and IL-8 were determined by ELISA. The number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels were measured. Patients' clinical manifestations were assessed by total nasal syndrome score (TNSS). Results: Expression of AMCase and IL-8 in patients with moderate and severe perineal allergic rhinitis were significantly elevated compared to the control group and patients with mild persistent allergic rhinitis. Serum levels of AMCase and IL-8 were associated with specific IgE, nasal eosinophil count, and TNSS. Conclusions: According to the results of this study, there might be a relationship between the expression of AMCase and IL-8 in nasal turbinate mucosa and the severity of allergic rhinitis. Keywords: AMCase; IL-8; allergic rhinitis; gene expression; inferior turbinate; nasal mucosa.

Item Type: Article
Subjects: WV Otolaryngology
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zeynab . bagheri
Date Deposited: 22 Feb 2021 05:09
Last Modified: 22 Feb 2021 05:09
URI: http://eprints.skums.ac.ir/id/eprint/8871

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