Synthesis and Characterization of Silk Fibroin- Coated Mesoporous Silica Nanoparticles for Tioguanine Targeting to Leukemia

Altememy, Dhiya and Khoobi, Mehdi and Akbari Javar, Hamid and Alsamarrai, Shaimaa and Khosravian, Pegah (2020) Synthesis and Characterization of Silk Fibroin- Coated Mesoporous Silica Nanoparticles for Tioguanine Targeting to Leukemia. International Journal of Pharmaceutical Research, 12 (sp2). ISSN 09752366

Full text not available from this repository.
Official URL: https://www.scopus.com/record/display.uri?eid=2-s2...

Abstract

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this work, large pore size MSNs were prepared by the co-condensation method. Tioguanine (TG) as a hydrophobic drug was loaded into the synthesized MSNs to prepare TG@MSNs. The results show MSNs were successfully synthesized and they have good loading efficiency and capacity for TG. Silk fibroin (SF) as an active targeting agent and pH-sensitive targeting release, is a natural protein from silkworm cocoons. It was used to coating MSNs to prepare SF/TG@MSNs. SF was Degummed and it was characterized by nuclear magnetic resonance (NMR), fourier transform infrared (FTIR) and field emission scanning electron microscopy (FESEM) methods. The MSNs were fully characterized by FESEM, transmission electron microscopy (TEM), zeta potential analysis, dynamic light scattering (DLS), nitrogen adsorption/desorption analysis, thermogravimetric analysis (TGA), X-ray diffraction (XRD) analysis, FTIR and UV-visible spectroscopies. The mechanism of TG release from SF/TG@MSNs were pH-sensitive. The in vitro release modeling revealed that TG released via the Higuchi model with fickian diffusion mechanism. In conclusion, SF/TG@MSNs exhibited a well synthesized and good payload for use in targeted drug delivery for leukemia.

Item Type: Article
Subjects: QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 21 Dec 2020 07:43
Last Modified: 21 Dec 2020 07:43
URI: http://eprints.skums.ac.ir/id/eprint/8787

Actions (login required)

View Item View Item