Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface

Nosrati, Hamed and Abpeikar, Zahra and Mahmoudian, Zahra Gholami and Zafari, Mahdi and Majidi, Jafar and Alizadeh, Akram and Moradi, Lida and Asadpour, Shiva (2020) Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface. Regenerative Medicine, 15 (8). ISSN 1746-0751

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Abstract

Currently, many corneal diseases are treated by corneal transplantation, artificial corneal implantation or, in severe cases, keratoprosthesis. Owing to the shortage of cornea donors and the risks involved with artificial corneal implants, such as infection transmission, researchers continually seek new approaches for corneal regeneration. Corneal tissue engineering is a promising approach that has attracted much attention from researchers and is focused on regenerative strategies using various biomaterials in combination with different cell types. These constructs should have the ability to mimic the native tissue microenvironment and present suitable optical, mechanical and biological properties. In this article, we review studies that have focused on the current clinical techniques for corneal replacement. We also describe tissue-engineering and cell-based approaches for corneal regeneration.

Item Type: Article
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Advanced Technologies > Department of Tissue Engineering
Depositing User: zeynab . bagheri
Date Deposited: 21 Dec 2020 07:04
Last Modified: 21 Dec 2020 07:04
URI: http://eprints.skums.ac.ir/id/eprint/8781

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