The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis

Cromwell, Elizabeth A and Schmidt, Chris A and Kwong, Kevin T and Pigott, David M and Mupfasoni, Denise and Biswas, Gautam and Shirude, Shreya and Hill, Elex and Donkers, Katie M and Abdoli, Amir and Abrigo, Michael R M and Adekanmbi, Victor and Adetokunboh, Olatunji O and Adinarayanan, Srividya and Ahmadpour, Ehsan and Ahmed, Muktar Beshir and Akalu, Temesgen Yihunie and Alanezi, Fahad Mashhour and Alanzi, Turki M and Alinia, Cyrus and Alipour, Vahid and Amit, Arianna Maever L and Anber, Nahla Hamed and Ancuceanu, Robert and Andualem, Zewudu and Anjomshoa, Mina and Ansari, Fereshteh and Antonio, Carl Abelardo T and Anvari, Davood and Appiah, Seth Christopher Yaw and Arabloo, Jalal and Arnold, Benjamin F and Ausloos, Marcel and Ayanore, Martin Amogre and Badirzadeh, Alireza and Baig, Atif Amin and Banach, Maciej and Baraki, Adhanom Gebreegziabher and Bärnighausen, Till Winfried and Bayati, Mohsen and Bhattacharyya, Krittika and Bhutta, Zulfiqar A and Bijani, Ali and Bisanzio, Donal and Bockarie, Moses John and Bohlouli, Somayeh and Bohluli, Mehdi and Butt, Zahid A and Cano, Jorge and Carvalho, Felix and Chattu, Vijay Kumar and Chavshin, Ali Reza and Cormier, Natalie Maria and Damiani, Giovanni and Dandona, Lalit and Dandona, Rakhi and Darwesh, Aso Mohammad and Daryani, Ahmad and Dash, Aditya Prasad and Deribe, Kebede and Deshpande, Aniruddha and Dessu, Blen Kassahun and Dhimal, Meghnath and Dianatinasab, Mostafa and Diaz, Daniel and Do, Hoa Thi and Earl, Lucas and El Tantawi, Maha and Faraj, Anwar and Fattahi, Nazir and Fernandes, Eduarda and Fischer, Florian and Foigt, Nataliya A and Foroutan, Masoud and Guo, Yuming and Hailu, Gessessew Bugssa and Hasaballah, Ahmed I and Hassankhani, Hadi and Herteliu, Claudiu and Hidru, Hagos Degefa de and Hole, Michael K and Hon, Julia and Hossain, Naznin and Hosseinzadeh, Mehdi and Househ, Mowafa and Humayun, Ayesha and Ilesanmi, Olayinka Stephen and Ilic, Irena M and Ilic, Milena D and Iqbal, Usman and Irvani, Seyed Sina Naghibi and Islam, M Mofizul and Jha, Ravi Prakash and Ji, John S and Johnson, Kimberly B and Jozwiak, Jacek Jerzy and Kabir, Ali and Kalankesh, Leila R and Kalhor, Rohollah and Karami Matin, Behzad and Karch, André and Karimi, Salah Eddin and Kasaeian, Amir and Kayode, Gbenga A and Kazemi Karyani, Ali and Kelbore, Abraham Getachew and Khafaie, Morteza Abdullatif and Khalilov, Rovshan and Khan, Junaid and Khatab, Khaled and Khater, Mona M and Khodayari, Mohammad Taghi and Kianipour, Neda and Kim, Yun Jin and Kinyoki, Damaris K and Kumar, G Anil and Kusuma, Dian and La Vecchia, Carlo and Lansingh, Van Charles and Lee, Paul H and LeGrand, Kate E and Levine, Aubrey J and Li, Shanshan and Maleki, Shokofeh and Mansournia, Mohammad Ali and Martins-Melo, Francisco Rogerlândio and Massenburg, Benjamin Ballard and Mayala, Benjamin K and Meitei, Wahengbam Bigyananda and Mendoza, Walter and Mengistu, Desalegn Tadese and Mereta, Seid Tiku and Mestrovic, Tomislav and Mihretie, Kebadnew Mulatu and Miller-Petrie, Molly K and Mohammadian-Hafshejani, Abdollah and Mohammed, Shafiu and Mokdad, Ali H and Moradi, Masoud and Moradzadeh, Rahmatollah and Moraga, Paula and Morrison, Shane Douglas and Mosser, Jonathan F and Mousavi, Seyyed Meysam and Munro, Sandra B and Muthupandian, Saravanan and mwingira, Upendo J and Naderi, Mehdi and Nagarajan, Ahamarshan Jayaraman and Naik, Gurudatta and Negoi, Ionut and Nguyen, Trang Huyen and Nguyen, Huong Lan Thi and Olagunju, Andrew T and Omar Bali, Ahmed and Osarenotor, Osayomwanbo and Osei, Frank B and Pasupula, Deepak Kumar and Pirsaheb, Meghdad and Pourjafar, Hadi and Rathi, Priya and Rawaf, David Laith and Rawaf, Salman and Rawassizadeh, Reza and Reiner, Robert C and Reta, Melese Abate and Rezapour, Aziz and Ribeiro, Ana Isabel and Rostami, Ali and Sabesan, Shanmugavelu and Sadeghi, Ehsan and Sajadi, S Mohammad and Samy, Abdallah M and Sartorius, Benn and Schaeffer, Lauren E and Shaikh, Masood Ali and Sharafi, Kiomars and Sharafi, Zeinab and Sharifi, Hamid and Shibuya, Kenji and Shin, Jae Il and Soheili, Amin and Soltani, Shahin and Spotin, Adel and Stolk, Wilma A and Tesfay, Berhe Etsay and Topor-Madry, Roman and Tran, Khanh Bao and Tran, Bach Xuan and Ullah, Irfan and Unnikrishnan, Bhaskaran and Vasseghian, Yasser and Vinkeles Melchers, Natalie V S and Violante, Francesco S and Yamada, Tomohide and Yaya, Sanni and Yazdi-Feyzabadi, Vahid and Yip, Paul and Yonemoto, Naohiro and Zaki, Leila and Zaman, Sojib Bin and Zamanian, Maryam and Zangeneh, Alireza and Zhang, Zhi-Jiang and Zhang, Yunquan and Ziapour, Arash and King, Jonathan D and Hay, Simon I (2020) The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis. The Lancet Global Health, 8 (9). e1186-e1194. ISSN 2214109X

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Abstract

Background: Lymphatic filariasis is a neglected tropical disease that can cause permanent disability through disruption of the lymphatic system. This disease is caused by parasitic filarial worms that are transmitted by mosquitos. Mass drug administration (MDA) of antihelmintics is recommended by WHO to eliminate lymphatic filariasis as a public health problem. This study aims to produce the first geospatial estimates of the global prevalence of lymphatic filariasis infection over time, to quantify progress towards elimination, and to identify geographical variation in distribution of infection. Methods: A global dataset of georeferenced surveyed locations was used to model annual 2000–18 lymphatic filariasis prevalence for 73 current or previously endemic countries. We applied Bayesian model-based geostatistics and time series methods to generate spatially continuous estimates of global all-age 2000–18 prevalence of lymphatic filariasis infection mapped at a resolution of 5 km2 and aggregated to estimate total number of individuals infected. Findings: We used 14 927 datapoints to fit the geospatial models. An estimated 199 million total individuals (95% uncertainty interval 174–234 million) worldwide were infected with lymphatic filariasis in 2000, with totals for WHO regions ranging from 3·1 million (1·6–5·7 million) in the region of the Americas to 107 million (91–134 million) in the South-East Asia region. By 2018, an estimated 51 million individuals (43–63 million) were infected. Broad declines in prevalence are observed globally, but focal areas in Africa and southeast Asia remain less likely to have attained infection prevalence thresholds proposed to achieve local elimination. Interpretation: Although the prevalence of lymphatic filariasis infection has declined since 2000, MDA is still necessary across large populations in Africa and Asia. Our mapped estimates can be used to identify areas where the probability of meeting infection thresholds is low, and when coupled with large uncertainty in the predictions, indicate additional data collection or intervention might be warranted before MDA programmes cease. Funding: Bill & Melinda Gates Foundation.

Item Type: Article
Subjects: WA Public Health > WA. 900 Vital Statistics
Divisions: Faculty of Health > Department of Epidemiology
Depositing User: zeynab . bagheri
Date Deposited: 21 Dec 2020 05:55
Last Modified: 21 Dec 2020 05:55
URI: http://eprints.skums.ac.ir/id/eprint/8780

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