Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress

Lorigooini, Zahra and Nasiri boroujeni, Shakiba and Balali-Dehkordi, Shima and Ebrahimi, Leila and Bijad, Elham and Rahimi-Madiseh, Mohammad and Amini-Khoei, Hossein (2020) Possible involvement of NMDA receptor in the anxiolytic-like effect of caffeic acid in mice model of maternal separation stress. Heliyon, 6 (9). e04833. ISSN 24058440

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Abstract

Background and aim: Anxiety disorders are one of the most common psychiatric disorders worldwide. Common anti-anxiety medications are associated with several side effects. Caffeic acid (CA) is a phenolic compound with several pharmacological effects. The aim of this study was to investigate the anxiolytic-like effect of CA in maternally separated (MS) mice focusing on the possible involvement of the NMDA receptor. Materials and methods: In this study, we used the MS paradigm (as a valid animal model of anxiety) in male mice and examined their anxiety-like behavior in postnatal day (PND) 45. The animals were divided into 12 experimental groups. Mice treated with CA alone and in combination with the NMDA receptor agonist/antagonist and then using open field (OFT) and elevated plus maze (EPM) anxiety-like behavior was assessed. Finally, the expression of NMDA receptor subtypes was assessed in the hippocampus using RT-PCR. Results: Finding showed that CA exerted anxiolytic-like effects in the OFT and EPM tests. We showed that administration of effective dose of NMDA significantly reversed the anxiolytic-like effect of effective dose of CA and co-administration of ketamine (a NMDA receptor antagonist) significantly potentiated the effect of sub-effective dose of CA. Furthermore, ketamine enhanced the CA-reducing effect on NMDA receptors in the MS mice. Conclusion: Our finding demonstrated that, probably at least, NMDA receptors are involved in the anxiety-like properties of CA in MS mice. Keywords:Maternal separation; Mice; Anxiety; Caffeic acid; Neuroscience; Pharmaceutical science; Molecular biology; Developmental biology

Item Type: Article
Subjects: QV pharmacology
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 07 Nov 2020 07:43
Last Modified: 07 Nov 2020 07:43
URI: http://eprints.skums.ac.ir/id/eprint/8692

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