A systematic review and meta-analysis: The effects of probiotic supplementation on metabolic profile in patients with neurological disorders

Tamtaji, Omid Reza and Milajerdi, Alireza and Reiner, Željko and Asemi, Zatollah and Dadgostar, Ehsan and Heidari-Soureshjani, Reza and Mamsharifi, Peyman and Amirani, Elaheh and Mirzaei, Hamed and Hallajzadeh, Jamal and Ghaderi, Amir (2020) A systematic review and meta-analysis: The effects of probiotic supplementation on metabolic profile in patients with neurological disorders. Complementary Therapies in Medicine, 53. p. 102507. ISSN 09652299

Full text not available from this repository.
Official URL: https://www.scopus.com/record/display.uri?eid=2-s2...

Abstract

Background and objective: The objective of meta-analysis of randomized controlled trials (RCTs) was to evaluate the effects of probiotic supplementation on metabolic status in patients with neurological disorders. Methods: The following databases were search up to April 2019: Pubmed, Scopus, Google scholar, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled by the use of the inverse variance method and expressed as mean difference with 95 % Confidence Intervals (95 % CI). Results: Nine studies were included in this meta-analysis. The findings suggested that probiotic supplementation resulted in a significant reduction in C-reactive protein (CRP) [Weighted Mean Difference (WMD): -1.06; 95 % CI: -1.80, -0.32] and malondialdehyde (MDA) levels (WMD: -0.32; 95 % CI: -0.46, -0.18). Supplementation with probiotics also significantly reduced insulin (WMD: -3.02; 95 % CI: -3.88, -2.15) and homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: -0.71; 95 % CI: -0.89, -0.52). Probiotics significantly reduced triglycerides (WMD: -18.38; 95 % CI: -25.50, -11.26) and VLDL-cholesterol (WMD: -3.16; 95 % CI: -4.53, -1.79), while they increased HDL-cholesterol levels (WMD: 1.52; 95 % CI: 0.29, 2.75). Conclusion: This meta-analysis demonstrated that taking probiotic by patients with neurological disorders had beneficial effects on CRP, MDA, insulin, HOMA-IR, triglycerides, VLDL-cholesterol and HDL-cholesterol levels, but did not affect other metabolic parameters.

Item Type: Article
Subjects: WL Nervous system
Divisions: Reserach Vice-Chancellar Department > student research center
Depositing User: zeynab . bagheri
Date Deposited: 24 Aug 2020 08:08
Last Modified: 24 Aug 2020 08:08
URI: http://eprints.skums.ac.ir/id/eprint/8650

Actions (login required)

View Item View Item