Autophagy and Ubiquitination as Two Major Players in Colorectal Cancer: Recent Patents Review

Saffari-Chaleshtori, Javad and Asadi-Samani, Majid and Rasouli, Maryam and Shafiee, Sayed Mohammad (2020) Autophagy and Ubiquitination as Two Major Players in Colorectal Cancer: Recent Patents Review. Recent Patents on Anti-Cancer Drug Discovery, 15. ISSN 15748928

Full text not available from this repository.
Official URL: https://pubmed.ncbi.nlm.nih.gov/32603286/

Abstract

Background: As one of the most commonly diagnosed cancers among men and women, colorectal cancer (CRC) leads to high rates of morbidity and mortality across the globe. Recent anti-CRC therapies are now targeting specific signaling pathways involved in colorectal carcinogenesis. Ubiquitin proteasome system (UPS) and autophagy are two main protein quality control systems, which play major roles in carcinogenesis of colorectal cancer. Balanced function of these two pathways is necessary for regulation of cell proliferation and cell death. Objective: In this systematic review, we will discuss the available evidence regarding the roles of autophagy and ubiquitination in progression and inhibition of CRC. Methods: The search terms "colorectal cancer" or "colon cancer" or "colorectal carcinoma" or "colon carcinoma" in combination with "ubiquitin proteasome" and "autophagy" were search of PubMed, Web of Science, and Scopus databases, and also Google Patents (https://patents.google.com) from January 2000 to Feb 2020. Results: The most important factors involved in UPS and autophagy have been investigated. There are many important factors involved in UPS and autophagy but this systematic review shows the most studies have focused on the role of ATG, 20s proteasome and mTOR in CRC, and the more important factors such as ATG8, FIP200, and TIGAR factors that are effective in the regulation of autophagy in CRC cells have not yet investigated. Conclusion: Focus on most important factors involved in UPS and autophagy such as ATG, 20s proteasome and mTOR, ATG8, FIP200, and TIGAR can be considered in drug therapy for controlling or activating autophagy. Keywords: Apoptosis; autophagy; cell proliferation; cell survival; colon cancer; ubiquitin proteasome system..

Item Type: Article
Subjects: WI Digestive System
QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zeynab . bagheri
Date Deposited: 20 Jul 2020 08:32
Last Modified: 20 Jul 2020 08:32
URI: http://eprints.skums.ac.ir/id/eprint/8631

Actions (login required)

View Item View Item