PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate

Yaghoobi, Hajar and Azizi, Hakim and Kholghi Oskooei, Vahid and Taheri, Mohammad and Ghafouri-Fard, Soudeh (2020) PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate. Meta Gene, 25. p. 100748. ISSN 22145400

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Abstract

PINK1 codes for a serine/threonine-protein kinase located in the mitochondria. This protein contributes in the pathophysiology of both neurodegenerative diseases and cancer. Its transcription has been shown to be regulated by a natural occurring antisense (AS) RNA named PINK1-AS. We examined expression levels of PINK1 and PINK1-AS in 54 breast cancer specimens versus their nearby non-cancerous tissues. We found significant down-regulation of PINK1 in tumoral tissues compared with nearby tissues (P = .003). Yet, expression of PINK1-AS was not remarkably different between tumoral tissues and nearby tissues. Relative expression of PINK1 was associated with mitotic rate (P = .03). We also found trends toward over-expression of PINK1 in younger patient compared with older patients (P = .09) and in grade 2 tumors compared with grade 3 ones (P = .08). The current study delivers further evidences for contribution of PINK1 in the pathophysiology of breast cancer and highlights the context-dependent properties the encoded protein.

Item Type: Article
Subjects: QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zeynab . bagheri
Date Deposited: 18 Jul 2020 05:50
Last Modified: 18 Jul 2020 05:50
URI: http://eprints.skums.ac.ir/id/eprint/8596

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