Hyperglycaemia and the risk of post-surgical adhesion

Ferns, Gordon A. and Hassanian, Seyed Mahdi and Arjmand, Mohammad-Hassan (2020) Hyperglycaemia and the risk of post-surgical adhesion. Archives of Physiology and Biochemistry. pp. 1-7. ISSN 1381-3455

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Official URL: https://pubmed.ncbi.nlm.nih.gov/32536284/

Abstract

Post-surgical adhesions are a major complication leading to organ dysfunctions, pain, intestinal obstruction, and infertility. The incidence of post-surgical adhesion is really high. The factors involved in the pathogenesis of post-surgical fibrosis, are largely unknown, for example why two patients with similar abdominal operation have a different risks of adhesion severity? High secretion of pro-inflammatory cytokines and growth factors, includes tumour necrosis factor α (TNF-α), interleukin 6 (IL6), and transforming growth factor β (TGF-β) by persistent recruitment of immune cells and the inappropriate proliferated fibroblast/mesothelial cells can stimulate signalling pathways particularly TGF-β leads to the up-regulation of some pro-fibrotic genes that impair fibrinolytic activity and promote extracellular matrix (ECM) accumulation. In this review, we focus on the role of diabetes and hyperglycaemia on post-surgical fibrosis, including the molecular mechanisms affected by hyperglycaemia that cause inflammation, oxidative stress, and increase the expression of pro-fibrotic molecules. Keywords: Hyperglycaemia; extracellular matrix deposition; inflammation; oxidative stress; post-surgical adhesion.

Item Type: Article
Subjects: WD Nutrition Disease and metabolic diseases
WO Surgery
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 21 Jun 2020 03:54
Last Modified: 21 Jun 2020 03:54
URI: http://eprints.skums.ac.ir/id/eprint/8563

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