Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

Parizadeh, Seyed Mostafa and Rezayi, Majid and Jafarzadeh-Esfehani, Reza and Avan, Amir and Ghazizadeh, Hamideh and Emadzadeh, Maryam and Sahebi, Reza and Ferns, Gordon A. and Ghayour-Mobarhan, Majid (2019) Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies. International Journal for Vitamin and Nutrition Research. pp. 1-13. ISSN 0300-9831

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Official URL: https://pubmed.ncbi.nlm.nih.gov/30816821/

Abstract

Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease. Keywords: Iran; Kidney disease; Liver disease; Vitamin D deficiency.

Item Type: Article
Subjects: WI Digestive System
WJ Urogenital System
QU Biochemistry > Nutrition.vitamins
Divisions: Faculty of Advanced Technologies > Department of Molecular Medicine
Depositing User: zeynab . bagheri
Date Deposited: 20 Jun 2020 07:53
Last Modified: 20 Jun 2020 07:53
URI: http://eprints.skums.ac.ir/id/eprint/8559

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