Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats

Asgharian, Shirin and Hojjati, Mohammad Reza and Ahrari, Mohsen and Bijad, Elham and Deris, Fatemeh and Lorigooini, Zahra (2020) Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats. Pharmaceutical Biology, 58 (1). pp. 447-453. ISSN 1388-0209

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Abstract

Context: There are numerous pharmacological activities for Ruta graveolens and its bioactive constituent, rutin, on learning and memory. Objective: This study aimed to examine the effect of R. graveolens and rutin on memory in rats. Materials and methods: In this study animals were treated with the hydroalcholic extract of R. graveolens and rutin by IP injection for 10 days. Behavioural and biochemical tests as well as HPLC analysis and antioxidant activity of extract have been evaluated. Results: R. graveolens extract and rutin significantly increased learning and improved spatial memory, as well as secondary latency; moreover, there were significant increases in the serum and brain antioxidant capacity as well as the level of TBARS in serum and brain tissues. Results also showed that R. graveolens has significant DPPH radical scavenging effect (IC50: 159.17 +/- 1.56 mu g/mL). The HPLC analysis of extract showed that caffeic acid (19.92 +/- 0.01), rutin (40.15 +/- 0.01), and apigenin (0.84 +/- 0.01) mg/g of dry extract are the main components of the extract. Discussion and conclusion: Regarding the effects of R. graveolens extract and rutin on animal brain cells, memory function, and learning, additional studies, including clinical trials, might be beneficial in producing natural supplementary drugs from this herb.

Item Type: Article
Subjects: QV pharmacology > QV 767 Traditional Pharmaceutics
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zeynab . bagheri
Date Deposited: 30 May 2020 08:14
Last Modified: 11 Nov 2020 04:30
URI: http://eprints.skums.ac.ir/id/eprint/8523

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