Clinical features of graves' ophthalmopathy and impact of enalapril on the course of mild graves’ ophthalmopathy: A pilot study

Ataabadi, Ghazal and Dabbaghmanesh, Mohammad H and Owji, Naser and Bakhshayeshkaram, Marzieh and Montazeri-Najafabady, Nima (2020) Clinical features of graves' ophthalmopathy and impact of enalapril on the course of mild graves’ ophthalmopathy: A pilot study. Endocrine, Metabolic and Immune Disorders - Drug Targets, 20 (1). pp. 139-148. ISSN 18715303

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Background: Inflammation, oxidative stress, and adipogenesis are associated with Graves’ ophthalmopathy (GO) progression. Objective: We conducted a pilot study to investigate the effect of Enalapril on patients with mild ophthalmopathy. Method: Based on the comprehensive eye examination, 12 patients with mild ophthalmopathy were selected from referred Graves’ patients and treated with Enalapril (5 mg daily) for 6 months. Clinical and ophthalmological examination [IOP (Intraocular Pressure), vision, Margin reflex distance and exophthalmia measurement, CAS (clinical activity score) and VISA [V (vision); I (inflamma-tion/congestion); S (strabismus/motility restriction); and A (appearance/exposure] score assessment) was performed at the beginning, 3 months and 6 months of the study period. Quality of life was also evaluated using a standard questionnaire. Results: Mean exophthalmia at the first visit was 18.75 ± 2.39, 3 months later 18.53 ± 2.39 and 6 months later was 17.92 ± 2.31, respectively. Mean CAS was 0.71 ± 0.82 (first visit), 0.57 ± 0.54 (3 months) and 0.14 ± 0.36 (6 months), respectively. Mean Margin reflex distance was 9.09 ± 4.36 (first visit) and 9.60 ± 4.40 (6 months), respectively. There were significant differences in the case of exophthalmia (P=0.002), CAS (P=0.006), and Margin reflex distance (P=0.029) between the first visit and 6 months after treatment. The difference between the score of quality of life in patients with GO after 6 months of follow up was statistically significant (P = 0.006). Conclusion: Our results showed that Enalapril treatment could ameliorate the clinical course of GO according to the ophthalmologic examinations and subjective parameters of disease progression. However, further studies should be performed to determine the efficacy of Enalapril in Graves’ ophthalmopathy treatment.

Item Type: Article
Uncontrolled Keywords: creatinine; enalapril; liothyronine; potassium; propylthiouracil; thiamazole; thyrotropin; thyroxine, adult; aged; Article; biochemical analysis; clincial activity score; clinical assessment; clinical examination; clinical feature; disease severity; drug efficacy; endocrine ophthalmopathy; enzyme linked immunosorbent assay; exophthalmos; eye examination; female; follow up; Graves Opthalmology Quality of Life questionnaire; human; hyperthyroidism; intraocular pressure; major clinical study; male; margin reflex distance; palpebral fissure; pilot study; quality of life; quality of life assessment; questionnaire; scoring system; vision; vision inflammation/congestion strabismus/motility restriction appearance/exposure score assessment; visual acuity; clinical trial
Subjects: WD Nutrition Disease and metabolic diseases
WK Endocrine System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Depositing User: zeynab . bagheri
Date Deposited: 26 May 2020 03:55
Last Modified: 26 May 2020 03:55

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