Exosomes: New insights into cancer mechanisms

Sahebi, Reza and Langari, Hadis and Fathinezhad, Zohre and Bahari Sani, Zahra and Avan, Amir and Ghayour Mobarhan, Majid and Rezayi, Majid (2020) Exosomes: New insights into cancer mechanisms. Journal of Cellular Biochemistry, 121 (1). pp. 7-16. ISSN 07302312

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Exosomes are mobile extracellular vesicles with a diameter 40 to 150 nm. They play a critical role in several processes such as the development of cancers, intercellular signaling, drug resistance mechanisms, and cell-to-cell communication by fusion onto the cell membrane of recipient cells. These vesicles contain endogenous proteins and both noncoding and coding RNAs (microRNA and messenger RNAs) that can be delivered to various types of cells. Furthermore, exosomes exist in body fluids such as plasma, cerebrospinal fluid, and urine. Therefore, they could be used as a novel carrier to deliver therapeutic nucleic-acid drugs for cancer therapy. It was recently documented that, hypoxia promotes exosomes secretion in different tumor types leading to the activation of vascular cells and angiogenesis. Cancer cell-derived exosomes (CCEs) have been used as prognostic and diagnostic markers in many types of cancers because exosomes are stable at 4°C and −70°C. CCEs have many functional roles in tumorigenesis, metastasis, and invasion. Consequently, this review presents the data about the therapeutic application of exosomes and the role of CCEs in cancer invasion, drug resistance, and metastasis.

Item Type: Article
Uncontrolled Keywords: 3,3' (1,4 phenylene)bisn 4 (4,5 dihydro 1h imidazol 2 yl)phenyl]acrylamide]; 5' nucleotidase; adenosine A2a receptor; CD39 antigen; epidermal growth factor receptor; exosomal protein; Fas ligand; interleukin 10; lapatinib; long untranslated RNA; Menkes protein; messenger RNA; microRNA; multidrug resistance associated protein 2; trastuzumab; tumor marker; tumor protein; unclassified drug; vasculotropin; Wilson disease protein, breast cancer; cancer diagnosis; cancer growth; cancer resistance; carcinogenesis; colorectal cancer; cytostasis; cytotoxicity; endocytosis; exosome; gene expression profiling; human; hypoxia; immune response; intracellular transport; lung cancer; malignant neoplasm; metastasis; molecularly targeted therapy; nonhuman; prostate cancer; proteomics; Review; stem cell self-renewal; tumor escape; tumor invasion; tumor microenvironment
Subjects: QY Clinical Pathology
Divisions: Faculty of Advanced Technologies > Department of Molecular Medicine
Depositing User: zeynab . bagheri
Date Deposited: 26 May 2020 08:07
Last Modified: 26 May 2020 08:07
URI: http://eprints.skums.ac.ir/id/eprint/8513

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