Growth factors as tools in photoreceptor cell regeneration and vision recovery

Forouzanfar, Fatemeh and Shojapour, Mana and Aghili, Zahra Sadat and Asgharzade, Samira (2020) Growth factors as tools in photoreceptor cell regeneration and vision recovery. Current Drug Targets, 21 (6). pp. 573-581. ISSN 13894501

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Photoreceptor loss is a major cause of blindness around the world. Stem cell therapy offers a new strategy in retina degenerative disease. Retinal progenitors can be derived from embryonic stem cells (ESC) in vitro, but cannot be processed to a mature state. In addition, the adult recipient retina presents a very different environment than the photoreceptor precursor donor. It seems that modulation of the recipient environment by ectopic development regulated growth factors for transplanted cells could generate efficient putative photoreceptors. The purpose of this review article was to investigate the signaling pathway of growth factors including: insulin-like growth factors (IGFs), fibroblast growth factors (FGF), Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Taurin and Retinoic acid (RA) involved in the differentiation of neuroretina cell, like; photoreceptor and retinal progenitor cells. Given the results available in the related literature, the differentiation efficacy of ESCs toward the photoreceptor and retinal neurons and the important role of growth factors in activating signaling pathways such as Akt, Ras/Raf1/ and ERKs also inhibit the ASK1/JNK apoptosis pathway. Manipulating differentiated culture, growth factors can influence pho-toreceptor transplantation efficiency in retinal degenerative disease.

Item Type: Article
Uncontrolled Keywords: adeno associated virus vector; brain derived neurotrophic factor; brain derived neurotrophic factor receptor; caspase 3; fibroblast growth factor; glial cell line derived neurotrophic factor; hypoxia inducible factor 1alpha; insulin; ionotropic receptor; microRNA; nerve growth factor; neurotrophic factor; okadaic acid; peripherin; protein p53; retinoic acid receptor alpha; rhodopsin; transforming growth factor beta1; vasculotropin, angiogenesis; apoptosis; autophosphorylation; cell differentiation; cell regeneration; cell survival; degenerative disease; diabetic retinopathy; eye development; gene expression; gene therapy; glaucoma; human; laser coagulation; mesenchymal stem cell; morphogenesis; nerve cell plasticity; neuroprotection; nonhuman; oxidative stress; pericyte; phagocytosis; photoreceptor cell; regenerative medicine; retina detachment; retina ganglion cell; retina injury; retina nerve cell; retinal pigment epithelium; Review; signal transduction; visual acuity
Subjects: WW Ophthalmology
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zeynab . bagheri
Date Deposited: 26 May 2020 05:22
Last Modified: 26 May 2020 05:22

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