A review of significant molecular mechanisms of flavonoids in prevention of prostate cancer

Ghasemi, S. and Lorigooini, Z. (2016) A review of significant molecular mechanisms of flavonoids in prevention of prostate cancer. Journal of Chemical and Pharmaceutical Sciences, 9 (4). pp. 3388-3394.


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Prostate cancer is the third most common cancer among men. Risk factors for prostate cancer contain environmental factors such as diet rich of reactive oxygen species. Epidemiological studies recommend dietary consumption of plant-derived foods may decrease the risk of prostate, colon, pancreas, breast and lung cancers. However, it has been difficult to identify specific components responsible for this effect. Many phytochemicals have been shown to be biologically active compounds and they may act as a protective factor against cancer. Recent researches have revealed that diets based on flavonoids have the potential benefits for cancer prevention. Flavonoids are part of a large class of polyphenols that are found widely in diet. Nowadays, experimental researches have suggested developing proof for the valuable action of flavonoids on multiple cancer-related biological pathways. Although the outcomes of studies about flavonoids and prostate cancer are still limited and conflicting, some protective associations have been suggested for flavonoid-rich foods. The current review presented molecular mechanism of the main flavonoids on prostate cancer. The main mechanisms are in three different directions. These mechanisms contain antioxidant activity and inhibition of DNA damage of its oxidizing agents, anti-cell proliferation and induction of apoptosis.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Flavonoids, Molecular mechanisms, Oxidative stress ,Prostate cancer
Subjects: WJ Urogenital System
QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 08 Jul 2017 07:51
Last Modified: 08 Jul 2017 07:51
URI: http://eprints.skums.ac.ir/id/eprint/848

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