Local Expression of Mucosal YKL-40; Correlation of YKL-40 with Clinical Manifestations and Immunopathogenesis of Moderate/Severe Persistent Allergic Rhinitis Patients

Pirayesh, Ashkan and Shahsavan, Shaghayegh and Zargari Samani, Omid and Shirzad, Hedyatollah and Amani, Soroush and Bagheri, Nader and Zamani, Mohammad Ali and Torkamand, Farbod and Moghni, Mandana and Deris, Fatemeh and Khazraei, Hamid Reza and Noormohammadian, Zahra (2020) Local Expression of Mucosal YKL-40; Correlation of YKL-40 with Clinical Manifestations and Immunopathogenesis of Moderate/Severe Persistent Allergic Rhinitis Patients. Immunological Investigations, 49 (1-2). pp. 46-57. ISSN 08820139

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Abstract

YKL-40 is an important protein that plays a critical role in chronic inflammation in hypersensitivity disease. In this study, the expression of YKL-40 was investigated among patients with moderate/severe persistent allergic rhinitis (M/S PAR), patients with mild (M) PAR and healthy individuals. Moreover, the association between YKL-40 and immunopathogenesis of M/S PAR was meticulously surveyed. For this purpose, surgical samples were tested by real-time polymerase chain reaction to evaluate YKL-40 mRNA expression. The presence and location of YKL-40 protein in the tissue samples were determined by immunohistochemistry. Additionally, we measured the number of eosinophils per field in the tissue samples, blood eosinophils, total serum IgE, specific serum IgE, total nasal syndrome score (TNSS) and YKL-40 serum levels. The data indicated that production of YKL-40 in patients with M/S PAR increased significantly when compared with the control group. Furthermore, local production of YKL-40 correlated with specific IgE, nasal eosinophil count and TNSS. The results of the present study indicate that YKL-40, for its correlation with allergic clinical manifestations and symptom severity in M/S PAR patients, should be considered as a trigger factor in AR.

Item Type: Article
Uncontrolled Keywords: chitinase 3 like protein 1; immunoglobulin E, adult; Article; clinical feature; controlled study; disease severity; eosinophil; eosinophil count; female; human; human cell; human tissue; immunoglobulin blood level; immunohistochemistry; immunopathogenesis; major clinical study; male; mRNA expression level; nose mucosa; nose obstruction; perennial rhinitis; priority journal; protein blood level; real time polymerase chain reaction; rhinorrhea; turbinate
Subjects: QU Biochemistry > Cell biology and genetics
WV Otolaryngology
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zeynab . bagheri
Date Deposited: 30 May 2020 04:09
Last Modified: 30 May 2020 04:09
URI: http://eprints.skums.ac.ir/id/eprint/8470

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