The current markers of cancer stem cell in oral cancers

Tahmasebi, Elahe and Alikhani, Milad and Yazdanian, Alireza and Yazdanian, Mohsen and Tebyanian, Hamid and Seifalian, Alexander (2020) The current markers of cancer stem cell in oral cancers. Life Sciences, 249. ISSN 00243205

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Head and neck cancer (HNC) constitute 5 of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown success at decreasing relapse and metastasis rates and improves the overall prognosis. Recently, target therapy and targeted drug delivery systems have been introduced as promising treatments. The elimination of efficiency of current therapeutic strategies due to the spared cancer stem cells that cause chemotherapy resistance, relapse and metastasis. Inefficiency methodologies in the elimination of all cancer cells in the body are a major problem that remained to be resolved before to confront the new cancer therapies. Many studies imply to cancer stem cell markers as important agents for targeted anti-cancer as well as improving chemotherapy efficiencies. The potentials of targeted cancer therapy led us to search for novel markers in the mouth cancer stem cells especially in rare cancers. The aimed of this research was, first a comprehensive critical review of the previous studies on the markers of cancer stem cells in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and to highlight the most common cancer stem cell markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis.

Item Type: Article
Uncontrolled Keywords: aldehyde dehydrogenase; BMI1 protein; CD133 antigen; CD147 antigen; CD24 antigen; G protein coupled receptor; Hermes antigen; leucine rich repeat containing G protein coupled receptor 5; musashi 1 protein; octamer transcription factor 4; RNA binding protein; scatter factor receptor; STAT3 protein; stem cell factor receptor; transcription factor NANOG; transcription factor Sox2; unclassified drug, adenoid cystic carcinoma; cancer growth; cancer prognosis; cancer stem cell; cell surface; clinical feature; embryonic stem cell; human; mouth cancer; mouth squamous cell carcinoma; mucoepidermoid tumor; nonhuman; prevalence; protein expression; renin angiotensin aldosterone system; Review; risk factor; salivary gland cancer; survival rate
Subjects: QZ pathology-Neoplasms
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine
Depositing User: zeynab . bagheri
Date Deposited: 30 May 2020 05:29
Last Modified: 30 May 2020 05:29

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