Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q 10 on hippocampal injury in mouse

Soleimani, Mansoureh and Golab, Fereshteh and Alizadeh, Akram and Rigi, Sara and Samani, Zeinab Nazarian and Vahabzadeh, Gelareh and Peirovi, Tahmineh and Sarbishegi, Maryam and Katebi, Majid and Azedi, Fereshteh (2019) Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q 10 on hippocampal injury in mouse. Journal of Cellular Physiology, 234 (10). pp. 18720-18730. ISSN 0021-9541

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Abstract

Electromagnetic fields (EMFs) are reported to interfere with chemical reactions involving free radical production. Coenzyme Q(10) (CoQ10) is a strong antioxidant with some neuroprotective activities. The purpose of this study was to examine and compare the neuroprotective effects of EMF and CoQ10 in a mouse model of hippocampal injury. Hippocampal injury was induced in mature female mice (25-30g), using an intraperitoneal injection of trimethyltin hydroxide (TMT; 2.5mg/kg). The experimental groups were exposed to EMF at a frequency of 50Hz and intensity of 5.9mT for 7hr daily over 1 week or treated with CoQ10 (10mg/kg) for 2 weeks following TMT injection. A Morris water maze apparatus was used to assess learning and spatial memory. Nissl staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) tests were also performed for the histopathological analysis of the hippocampus. Antiapoptotic genes were studied, using the Western blot technique. The water maze test showed memory improvement following treatment with CoQ10 and coadministration of CoQ10+EMF. The Nissl staining and TUNEL tests indicated a decline in necrotic and apoptotic cell count following treatment with CoQ10 and coadministration of CoQ10+EMF. The Western blot study indicated the upregulation of antiapoptotic genes in treatment with CoQ10, as well as coadministration. Also, treatment with EMF had no significant effects on reducing damage induced by TMT in the hippocampus. According to the results, EMF had no significant neuroprotective effects in comparison with CoQ10 on hippocampal injury in mice. Nevertheless, coadministration of EMF and CoQ10 could improve the neuroprotective effects of CoQ10.

Item Type: Article
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Advanced Technologies > Department of Tissue Engineering
Depositing User: zeynab . bagheri
Date Deposited: 20 May 2020 05:35
Last Modified: 20 May 2020 05:35
URI: http://eprints.skums.ac.ir/id/eprint/8443

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