Validation of an analytical method for determination of 13 priority polycyclic aromatic hydrocarbons in mineral water using dispersive liquid-liquid microextraction and GC-MS

Sadeghi, R. and Kobarfard, F. and Yazdanpanah, H. and Eslamizad, S. and Bayat, M. (2016) Validation of an analytical method for determination of 13 priority polycyclic aromatic hydrocarbons in mineral water using dispersive liquid-liquid microextraction and GC-MS. Iranian Journal of Pharmaceutical Research, 15 (1). pp. 157-168.

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Abstract

Dispersive liquid-liquid microextraction (DLLME) combined with gas chromatography–mass spectrometry (GC–MS) was used for the extraction and determination of 13 polycyclic aromatic hydrocarbons (PAHs) in mineral water samples. In this procedure, the suitable combination of extraction solvent (500 μL chloroform) and disperser solvent (1000 μL acetone) were quickly injected into the water sample (10.00 mL) by Hamilton syringe. After centrifugation, 500 μL of the lower organic phase was dried under a gentle stream of nitrogen, re-dissolved in chloroform and injected into GC-MS. Chloroform and acetone were found to be the best extraction and disperser solvent, respectively. Validation of the method was performed using spiked calibration curves. The enrichment factor ranged from 93 to 129 and the recovery ranged from 71 to 90%. The linear ranges for all the PAHs were 0.10-2.80 ngmL-1. The relative standard deviations (RSDs) of PAHs in water by using anthracene-d10 as internal standard, were in the range of 4-11% for most of the analytes (n = 3). Limit of detection (LOD) for different PAHs were between 0.03 and 0.1 ngmL-1. The method was successfully applied for the analysis of PAHs in mineral water samples collected from Tehran. © 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Dispersive liquid-liquid microextraction (DLLME),GC-MS ,Iran, Mineral water, Polycyclic aromatic hydrocarbons (PAHs)
Subjects: WA Public Health > Public Health Education WA.18 > WA 30 Social, Economic, and Environmental factor in public health
WA Public Health > WA 30 Social, Economic, and Environmental factor in public health
Divisions: Faculty of Health > Department of Environmental Health
Depositing User: zahra bagheri .
Date Deposited: 08 Jul 2017 06:04
Last Modified: 08 Jul 2017 06:04
URI: http://eprints.skums.ac.ir/id/eprint/836

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