Correlation of endothelial nitric oxide synthase gene polymorphism (GG, TT and GT genotype) with proteinuria and retinopathy in type 2 diabetic patients

Momeni, Ali. and Hashemzadeh-Chaleshtori, Morteza. and Saadatmand, Saeed. and Kheiri, Soleiman. (2016) Correlation of endothelial nitric oxide synthase gene polymorphism (GG, TT and GT genotype) with proteinuria and retinopathy in type 2 diabetic patients. Journal of Clinical and Diagnostic Research, 10 (2). OC32-OC35.

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Abstract

Background: Nephropathy is the most important leading cause of end stage renal failure in type 2 diabetic patients, so numerous studies were done to diagnose and evaluate risk factors of diabetic nephropathy (DN). Some gene polymorphisms may be associated with progression or regression of DN, so the aim of this study was to compare prevalence of eNOS gene polymorphism in diabetic patients with controls and its association with diabetic nephropathy. Materials and Methods: In a cross-sectional study, 94 type 2 diabetic patients and 94 normal participants were enrolled. Patients without retinopathy were excluded from this study. For all of the patients, fasting blood sugar (FBS), 2 hours post-prandial (BS), Blood Urea Nitrogen (BUN), Creatinine (Cr), 24 hours urine protein were measured in the case group. Endothelial nitric oxide synthetase gene polymorphism was evaluated in the case and control groups. Results: There was no significant difference based on age and sex between patients in case and control groups. GG genotype of eNOS was less common in the patient group compared to control group. There was no difference between prevalence of TT, GT or GG genotype based on age and sex. There was no correlation between diabetic retinopathy or proteinuria and genotypes of eNOs. Conclusion: The study showed that in type 2 diabetic patients, NOS gene polymorphism was more common compared to normal population; however, there is no correlation between this gene polymorphism and proteinuria or retinopathy in these patients.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: ENOSو Nephropathyو Retinopathy
Subjects: WJ Urogenital System
WW Ophthalmology
Divisions: Faculty of Health > Department of Epidemiology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Biochemistry and Genetics
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zahra bagheri .
Date Deposited: 08 Jul 2017 04:46
Last Modified: 20 May 2018 04:49
URI: http://eprints.skums.ac.ir/id/eprint/824

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