Exploring changes in thalamus metabolites as diagnostic biomarkers in idiopathic generalised epilepsy patients using magnetic resonance spectroscopy

Abedi-Firouzjah, Razzagh and Rostamzadeh, Ayoob and Banae, Amin and Shafiee, Mohsen and Masoumi Moghaddam, Zafar and Vafapour, Hassan (2020) Exploring changes in thalamus metabolites as diagnostic biomarkers in idiopathic generalised epilepsy patients using magnetic resonance spectroscopy. Malaysian Journal of Medical Sciences, 27 (1). ISSN 1394195X

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Abstract

Introduction: Idiopathic generalised epilepsy (IGE) refers to a group of epilepsies resulting from the activation of neurons in the whole brain. This study aimed to evaluate the metabolite changes in thalamus as diagnostic biomarkers in IGE patients compared to healthy individuals using magnetic resonance spectroscopy (MRS) technique. Methods: The MRS was performed on 35 IGE patients (26 women and 11 men) with average age of 32 (ranged from 18 to 43) and 35 healthy individuals (13 women and 22 men) with average age of 31 (ranged from 21 to 50) as the control group. The levels of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) were measured using MRS. The NAA/Cr and NAA/Cho ratios were calculated for all participants. These values were statistically compared using t-test between the groups. Results: The NAA had significant lower values in IGE patients, 9.6 (SD = 0.8) and 9.9 (SD = 0.7) for right and left thalamus, respectively, compared to 10.9 (SD = 0.9) and 10.7 (SD = 0.9) in control group. The Cr values in the left side of thalamus were significantly higher in IGE patients (6.7 [SD = 0.8] versus 5.8 [SD = 0.5]); however, there was no difference in right thalamus. Measurements showed no difference for amounts of Cho between the groups in both sides of thalamus. The NAA/Cr ratio was 1.48 (SD = 0.14) and 1.48 (SD = 0.16) for right and left thalamus, respectively, in IGE patients in comparison with 1.83 (SD = 0.2) and 1.86 (SD = 0.26) in controls. There was no meaningful variation between the NAA/Cho ratio of the right and left thalamus among the groups. Conclusion: Thalamic NAA, Cr and NAA/Cr ratio values in IGE patients showed statistical differences compared to healthy individuals. Evaluating metabolites variations in thalamus using MRS is suggested for differentiating IGE patients from healthy individuals. keywords: Epilepsy, MRI, MRS, Spectroscopy

Item Type: Article
Subjects: WL Nervous system
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Depositing User: zeynab . bagheri
Date Deposited: 25 Apr 2020 05:31
Last Modified: 25 Apr 2020 05:31
URI: http://eprints.skums.ac.ir/id/eprint/8180

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