A Review of Mitochondrial Biogenesis and Cellular Response

Noshadi, Esmat and Arshi, Asghar and Mahmoudi, Esmaeil and Jamshidian, Hasan and Dehghani Samani, Mina and Hashemzehi, Rasoul and Fadaei, Mehdi (2019) A Review of Mitochondrial Biogenesis and Cellular Response. Scientific Journal of Iranian Blood Transfusion Organization, 16 (2). ISSN 1735-8248

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Abstract

Background and Objectives Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly play an important part in aging. Materials and Methods Because of the mitochondrial relationship with some factors such as matrix proteins, cell cycle and evolution, in this review article we examined the mitochondrial relationship with these factors and mechanisms. The data were extracted from NCBI and SID databases. Results Changes and mutations in mitochondria are common in most of the molecular processes and important diseases including cancer, but these mutations do not result in mitochondria deactivation. Investigating these pathways helps us to identify and treat diseases such as cancer. Conclusions The mitochondria is the most important source of cellular energy supply, and mitochondrial damage can interfere with cellular activity and reduce the amount of energy produced and increase the production of free radicals. Mitochondria biogenesis is one of the protective methods of the cell against oxidative stress, which has a cell protective role. Keywords: Mitochondria , Organelle Biogenesis , DNA

Item Type: Article
Subjects: QU Biochemistry
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Depositing User: zeynab . bagheri
Date Deposited: 19 Feb 2020 10:24
Last Modified: 19 Feb 2020 10:24
URI: http://eprints.skums.ac.ir/id/eprint/8129

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