The effect of symbiotic supplementation on liver enzymes, c‑reactive protein and ultrasound findings in patients with non‑alcoholic fatty liver disease: A clinical trial

Asgharian, A. and Askari, G. and Esmailzade, A. and Feizi, A. and Mohammadi, V. (2016) The effect of symbiotic supplementation on liver enzymes, c‑reactive protein and ultrasound findings in patients with non‑alcoholic fatty liver disease: A clinical trial. International Journal of Preventive Medicine, 2016-M.

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Abstract

Background: Regarding to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), concentrating on various strategies to its prevention and management seems necessary. The aim of this study was to determine the effects of symbiotic on C‑reactive protein (CRP), liver enzymes, and ultrasound findings in patients with NAFLD. Methods: Eighty NAFLD patients were enrolled in this randomized, double‑blind, placebo‑controlled clinical trial. Participants received symbiotic in form of a 500 mg capsule (containing seven species of probiotic bacteria and fructooligosaccharides) or a placebo capsule daily for 8 weeks. Ultrasound grading, CRP, and liver enzymes were evaluated at the baseline and the end of the study. Results: In the symbiotic group, ultrasound grade decreased significantly compared to baseline (P < 0.005) but symbiotic supplementation was not associated with changes in alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. In the placebo group, there was no significant change in steatosis grade whereas ALT and AST levels were significantly increased (P = 0.002, P = 0.02, respectively). CRP values remained static in either group. Conclusions: Symbiotic supplementation improved steatosis in NAFLD patients and might be useful in the management of NAFLD or protective against its progression. © 2016 International Journal of Preventive Medicine.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: Liver steatosis, Nonalcoholic fatty liver disease, Symbiotic
Subjects: WK Endocrine System
QU Biochemistry
Divisions: Faculty of Medicine
Depositing User: zahra bagheri .
Date Deposited: 05 Jul 2017 08:04
Last Modified: 05 Jul 2017 08:04
URI: http://eprints.skums.ac.ir/id/eprint/809

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