Prevalence of extended-spectrum beta-lactamase-producing Klebsiella Pneumoniae isolates in nosocomial and community-acquired urinary tract infections

Latifpour, M. and Gholipour, A. and Damavandi, M.S. (2016) Prevalence of extended-spectrum beta-lactamase-producing Klebsiella Pneumoniae isolates in nosocomial and community-acquired urinary tract infections. Jundishapur Journal of Microbiology, 9 (3).

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Abstract

Background: Klebsiella pneumoniae is a family member of Enterobacteriaceae. Isolates of K. pneumoniae produce enzymes that cause decomposition of third generation cephalosporins. These enzymes are known as extended-spectrum beta-lactamase (ESBL). Resistance of K. pneumoniae to beta-lactamase antibiotics is commonly mediated by beta-lactamase genes. Objectives: The aim of this study was to identify the ESBL produced by K. pneumoniae isolates that cause community-acquired and nosocomial urinary tract infections within a one-year period (2013 to 2014) in Kashani and Hajar university hospitals of Shahrekord, Iran. Patients and Methods: From 2013 to 2014, 150 strains of K. pneumoniae isolate from two different populations with nosocomial and community-acquired infections were collected. The strains were then investigated by double disk synergism and multiplex polymerase chain reaction (PCR). Results: The study population of 150 patients with nosocomial and community-acquired infections were divided to two groups of 75 each. We found that 48 of the K. pneumoniae isolates in the patients with nosocomial infection and 39 isolates in those with community-acquired infections produced ESBL. The prevalence of TEM1, SHV1 and VEB1 in ESBL-producing isolates in nosocomial patients was 24%, 29.3% and 10.6%, and in community-acquired patients, 17.3%, 22.7% and 8%, respectively. Conclusions: Theprevalence of ESBL-producing K. pneumoniae isolate is of great concern; therefore, continuous investigationseems essential to monitor ESBL-producing bacteria in patients with nosocomial and community-acquired infections. © 2016, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: Beta-lactamase SHV-1, Beta-lactamase TEM-1, Beta-lactamase VEB-1, Beta-lactamases, Klebsiella pneumoniae
Subjects: WC Communicable Diseases
WJ Urogenital System
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Microbiology
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 05 Jul 2017 07:59
Last Modified: 05 Jul 2017 07:59
URI: http://eprints.skums.ac.ir/id/eprint/808

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