The effect of pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat

Solati, Kamal and Rabiei, Zahra and Asgharzade, Samira and Amini-Khoei, Hossein and Hassanpour, Ali and Abbasiyan, Zahra and Anjomshoa, Maryam and Rafieian-Kopaei, Mahmoud (2019) The effect of pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat. AIMS Neuroscience.

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Abstract

The aim of present study is to investigate pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days. The intervention groups received A. officinarum extract at different doses (50, 100 and 150 mg/kg) 30 minutes before PTZ injection. A. officinarum extract treatment in rats with PTZ-induced kindling exerted significant increase in seizure latency and significant decrease in the frequency of total body seizure, frequent spinning, and jumping. Flumazenil significantly inhibited the antiepileptic effects of A. officinarum extract in the rat receiving the extract at 150 mg/kg. A. officinarum extract can inhibit PTZ-induced seizure and memory impairment, and therefore can be considered as a potent agent which warranted further research to clarify its effects. Keywords Author Keywords:Alpinia officinarum; seizure; pentylentetrazol; memory KeyWords Plus:OXIDATIVE STRESS; EPILEPSY

Item Type: Article
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: marzieye nazari .
Date Deposited: 05 Nov 2019 05:45
Last Modified: 05 Nov 2019 05:45
URI: http://eprints.skums.ac.ir/id/eprint/8003

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