Evaluation of multiple sclerosis patients through structural biomarkers of diffusion tensor magnetic imaging and correlation with clinical features

Fatehi, D. and Naleini, F. and Salehi, M.G. and Gharib, A. and Farzizadeh, M. and Rostamzadeh, A. (2016) Evaluation of multiple sclerosis patients through structural biomarkers of diffusion tensor magnetic imaging and correlation with clinical features. Journal of Chemical and Pharmaceutical Sciences, 9 (2). pp. 830-837.

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Abstract

Introduction: Diffusion tensor imaging (DTI) is an imaging technique with quantity measuring capability which enables to overcome limitations of conventional magnetic resonance imaging (MRI) and provides beneficial information concerning microscopic structures. This study aims to evaluate pathological changes in the brain tissue of multiple sclerosis (MS) patients using mean diffusivity (MD) and fractional anisotropy (FA) values in DTI technique. Methods: A total of 45 patients with a definite diagnosis of MS with attacks relapse and 20 healthy individuals were underwent both conventional MRI and DTI. In order to evaluate progression of the neural damages in these patients, expanded disability status scale (EDSS) was recorded. The location of MS plaques and normal appearing white matter (NAWM) was determined by MRI and brain sequences were studied axial T2W, axial T2W-FLAIR, sagittal T2W-FLAIR and coronal T2W. Results: The mean of the variable MD from MS plaques (Mean=4.3±1.01) compared to of the variable MD from NWM (mean=2.1±1.1) has significant difference (P=0.00001). Moreover, mean of the FA plaques (Mean=0.24±0.05) showed significant (P=0.00001) compared to NWM (Mean=0.55±0.56). In addition, mean of FA from the NAWM of the patients (Mean=0.42±0.11) was significantly different from NWM (P=0.00001). MD values of NAWM of the patients demonstrated significant association with EDSS of the patients (P=0.004). Conclusion: The important point in conventional MRI is that high density lesions which demand long echo time only offer an inconsiderable sign of the disease. As a result, in completing evaluation of the damages to tissue surrounding the plaques it is suggested that advanced imaging techniques such as DTI are carried out as a routine procedure in MS patients.

Item Type: Article
Additional Information: cited By 12
Uncontrolled Keywords: Cellular Imagingو Diffusion tensor magnetic resonance imagingو Imaging biomarkerو Multiple sclerosisو Neuroimaging
Subjects: WL Nervous system
WN Radiology . Diagnostic Imaging
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Medical Physics
Depositing User: zahra bagheri .
Date Deposited: 05 Jul 2017 06:55
Last Modified: 05 Jul 2017 06:55
URI: http://eprints.skums.ac.ir/id/eprint/800

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